Results 151 to 160 of about 1,170,924 (343)

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Thermal Burns and Smoke Inhalation Injuries [PDF]

, 2015
In this pathophysiology paper, the reader is presented with a profile of an elderly patient who recently suffered thermal burns and smoke inhalation injuries as a result of a nursing home fire.
Cox, Anna
core   +1 more source

Pulmonary Edema in Hypertensive Patients with Diastolic Heart Dysfunction: About 200 Cases

, 2020
Sanaa Drissi, Najat Mouine, Amine Elhassnaoui, Asmaa Boulehjour   +3 more
openalex   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Time to Resolution of Diabetic Macular Edema after Treatment with Intravitreal Aflibercept Injection or Laser in VISTA and VIVID

, 2022
Carolina C. S. Valentim, Rishi P. Singh, Weiming Du, Hadi Moini, Katherine E. Talcott   +4 more
openalex   +1 more source

Pathophysiology and treatment of cerebral edema in traumatic brain injury

Neuropharmacology, 2019
R. Jha, P. Kochanek, M. Simard
semanticscholar   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Dermatomyositis associated with hyponatremia and anasarca

JAAD Case Reports, 2021
Madison Grinnell, BA, Emily Keyes, BA, Thomas Vazquez, BS, Josef Concha, MD, DeAnna Diaz, MS, MBS, Margaret Wat, MD, PhD, Rosalie Elenitsas, MD, Victoria P. Werth, MD   +7 more
doaj   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Perilead Edema in Deep Brain Stimulation: Long-Term Outcomes and Etiologic Correlates [PDF]

Luigi Gianmaria Remore, Giorgio Fiore, Elena Pirola, Linda Borellini, Francesca Mameli, Fabiana Ruggiero, Eleonora Zirone, Roberta Ferrucci, Filippo Cogiamanian, Enrico Mailland, Antonella Ampollini, Giulio Bertani, Elena Scagliotti, Stefania Elena Navone, Giovanni Marfia, Ioannis U. Isaias, Marco Locatelli   +16 more
openalex   +1 more source