Results 21 to 30 of about 4,143 (137)

Biomedical Text Link Prediction for Drug Discovery: A Case Study with COVID-19

Pharmaceutics, 2021
Link prediction in artificial intelligence is used to identify missing links or derive future relationships that can occur in complex networks. A link prediction model was developed using the complex heterogeneous biomedical knowledge graph, SemNet, to ...
Kevin McCoy, Sateesh Gudapati, Lawrence He, Elaina Horlander, David Kartchner, Soham Kulkarni, Nidhi Mehra, Jayant Prakash, Helena Thenot, Sri Vivek Vanga, Abigail Wagner, Brandon White, Cassie S. Mitchell   +12 more
doaj   +1 more source

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis†

Photochemistry and Photobiology, Volume 99, Issue 2, Page 437-447, March/April 2023., 2023
Mechanisms of action when 5‐fluorouracil (5FU) and photodynamic therapy (PDT) are combined to treat squamous precancer lesions. 5FU inhibits thymidylate synthase, damages DNA and RNA and activates p53. 5FU also induces antitumor immunity by suppressing myeloid‐derived suppressor cells, activating damage‐associated molecules (DAMPs), recruiting immune ...
Sanjay Anand, Lauren E. Heusinkveld, Cheng‐En Cheng, Lefatshe Lefatshe, Pushpamali De Silva, Tayyaba Hasan, Edward V. Maytin   +6 more
wiley   +1 more source

Plasma matrix metalloproteinase 2 is associated with severity and mortality in pulmonary arterial hypertension

Pulmonary Circulation, Volume 12, Issue 1, January 2022., 2022
Abstract Pulmonary arterial hypertension (PAH) is a life‐threatening disease characterized by vasoconstriction and remodeling of the pulmonary vessels. Risk stratification in PAH could potentially be improved by including novel biomarkers related to PAH pathobiology.
Mattias Arvidsson, Abdulla Ahmed, Joanna Säleby, Roger Hesselstrand, Göran Rådegran   +4 more
wiley   +1 more source

A scoring system for predicting downgrading and resolution of high‐grade infant vesicoureteral reflux

Acta Paediatrica, Volume 110, Issue 1, Page 347-356, January 2021., 2021
Abstract Aim Aim of the study was to provide a scoring system for predicting downgrading and resolution of infantile high‐grade vesicoureteral reflux (VUR). Methods Eighty‐nine infants (65 boys) with high‐grade VUR (grade 4‐5) diagnosed at median age 2.5 months and followed to 39 months had repeated investigations of VUR grade, renal damage/function ...
Sofia Sjöström, Aldina Pivodic, Kate Abrahamsson, Rune Sixt, Eira Stokland, Sverker Hansson   +5 more
wiley   +1 more source

Metabolomic Profiling Revealed Potential Biomarkers in Patients With Moyamoya Disease

Frontiers in Neuroscience, 2020
Metabolomics is increasingly used to observe metabolic patterns and disease-specific metabolic biomarkers. However, serum metabolite analysis of moyamoya disease (MMD) is rarely reported.
Chunmei Geng, Changmeng Cui, Yujin Guo, Changshui Wang, Jun Zhang, Wenxiu Han, Feng Jin, Dan Chen, Pei Jiang   +8 more
doaj   +1 more source

Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults

Mediators of Inflammation, Volume 2021, Issue 1, 2021., 2021
Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified.
Wellington F. Rodrigues, Camila B. Miguel, Ferdinando Agostinho, Gabriela V. da Silva, Javier E. Lazo-Chica, Sandra M. Naressi Scapin, Marcelo H. Napimoga, Carlos A. Trindade-da-Silva, José E. Krieger, Alexandre da Costa Pereira, Carlo J. Freire Oliveira, Siomar de Castro Soares, Carlos Ueira-Vieira, Alex Kleinjan   +13 more
wiley   +1 more source

Apical microleakage of different root canal sealers after use of maleic acid and EDTA as final irrigants

Brazilian Oral Research, 2014
This study aimed to compare the effects of ethylenediaminetetraacetic acid (EDTA) and maleic acid (MA) on the sealing ability of various root canal sealers. Eighty root canals were instrumented and irrigated with either EDTA or MA. They were divided into
Özgür İlke ULUSOY, Yelda NAYIR, Kezban ÇELIK, Sis Darendeliler YAMAN   +3 more
doaj   +1 more source

False Positive Phenotypic Detection of Metallo-Beta-Lactamases in Acinetobacter Baumannii

Acta Clinica Croatica, 2019
Phenotypic detection of metallo-β-lactamases (MBLs) in Acinetobacter (A.) baumannii is a serious challenge to clinical microbiologists. MBLs are inhibited by metal chelators such as ethylenediaminetetraacetic acid) (EDTA).
Branka Bedenić, Ranko Ladavac, Mirna Vranić-Ladavac, Nada Barišić, Natalie Karčić, Katherina Bernadette Sreter, Slobodan Mihaljević, Luka Bielen, Haris Car, Nataša Beader   +9 more
doaj   +1 more source

Frontiers in translational systemic sclerosis research: A focus on the unmet 'cutaneous' clinical needs (Viewpoint)

Experimental Dermatology, Volume 29, Issue 12, Page 1144-1153, December 2020., 2020
Abstract This viewpoint considers four cutaneous unmet clinical needs of patients with systemic sclerosis (SSc), namely the rapidly progressive skin thickening (scleroderma) which occurs early on in diffuse cutaneous disease; digital (finger and toe) ulcers; calcinosis; and cutaneous telangiectases.
Ariane L. Herrick, Rudresh Shukla, Rachel E. B. Watson   +2 more
wiley   +1 more source

Skeletal stem cell‐mediated suppression on inflammatory osteoclastogenesis occurs via concerted action of cell adhesion molecules and osteoprotegerin

STEM CELLS Translational Medicine, Volume 9, Issue 2, Page 261-272, February 2020., 2020
Abstract In the current study, we investigated how skeletal stem cells (SSCs) modulate inflammatory osteoclast (OC) formation and bone resorption. Notably, we found that intercellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), and osteoprotegerin (OPG) play a synergistic role in SSC‐mediated suppression of inflammatory ...
Xin Li, Li Ding, Yu‐Xing Wang, Zhong‐Li Li, Qian Wang, Zhi‐Dong Zhao, Sen Zhao, Hua Wang, Chu‐Tse Wu, Ning Mao, Heng Zhu   +10 more
wiley   +1 more source