Results 91 to 100 of about 4,584 (263)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimally edge-colouring outerplanar graphs is in NC [PDF]

We prove that every outerplanar graph can be optimally edge-coloured in polylogarithmic time using a polynomial number of processors on a parallel random access machine without write conflicts (P-RAM)
Gibbons, Alan (Alan M.), Rytter, Wojciech   +1 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Textile material multi ply cutting by laser [PDF]

Tekstilna industrija
Multi ply fabric cutting by laser is very challenging because of low thermal conductivity of textile materials. A laser beam can through-cut only limited number of fabric plies placed one above another.
Stoyanov Borislav, Nemeša Ineta, Pešić Marija, Bukhonka Nadia, Bozoki Valentina   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

L- Edge Colouring of Graphs

International Journal of Mathematics and Soft Computing, 2013
A graph G = (V, E) is said to be topogenic if it admits a topogenic set indexer, which is a set indexer f: Viƒ  2X such that f(V) f (E) iƒ… is a topology on X. A list colouring of a graph G = (V,E) with a colour list C = i» i€¨ i€© i€¨ i€© i½ 1 2 , , ....
A. Uma Devi, R. B. Gnana Jothi
openaire   +1 more source

Wild edge colourings of graphs

Journal of Symbolic Logic, 2004
AbstractWe prove consistent, assuming there is a supercompact cardinal, that there is a singular strong limit cardinalμ, of cofinalityω, such that everyμ+-chromatic graphXonμ+has an edge colouringcofXintoμcolours for which every vertex colouringgofXinto at mostμmany colours has ag-colour class on whichctakes every value.The paper also contains some ...
Dzamonja, Mirna, Komjáth, Péter, Morgan, Charles   +2 more
openaire   +5 more sources

Some snarks are worse than others

, 2020
Many conjectures and open problems in graph theory can either be reduced to cubic graphs or are directly stated for cubic graphs. Furthermore, it is known that for a lot of problems, a counterexample must be a snark, i.e.
Mazzuoccolo, Giuseppe, Mkrtchyan, Vahan, Máčajová, Edita, Zerafa, Jean Paul   +3 more
core