Results 101 to 110 of about 4,584 (263)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

On upper chromatic number for SQS(10) and SQS(16)

open access: yesLe Matematiche, 1995
A mixed hypergraph is characterized by the fact that it possesses anti-edges as well as edges. In a colouring of a mixed hypergraph, every anti-edge has at least two vertices of the same colour and every edge has at least two vertices coloured ...
Lorenzo Milazzo
doaj  

Fibonacci and Telephone Numbers in Extremal Trees

open access: yesDiscussiones Mathematicae Graph Theory, 2018
In this paper we shall show applications of the Fibonacci numbers in edge-coloured trees. In particular we determine the successive extremal graphs in the class of trees with respect to the number of (A, 2B)-edge colourings.
Bednarz Urszula, Włoch Iwona
doaj   +1 more source

THE ENTIRE FACE IRREGULARITY STRENGTH OF A BOOK WITH POLYGONAL PAGES

open access: yesBarekeng, 2015
A face irregular entire labeling is introduced by Baca et al. recently, as a modification of the well-known vertex irregular and edge irregular total labeling of graphs and the idea of the entire colouring of plane graph.
Meilin I. Tilukay, Venn Y. I. Ilwaru
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The optimal edge-colouring threshold

open access: yes, 2022
Consider any dense r-regular quasirandom bipartite graph H with parts of size n and fix a set of r colours. Let L be a random list assignment where each colour is available for each edge of H with probability p. We show that the threshold probability for H to have a proper L-edge-colouring is p of order (log n)/n. This answers a question of Kang, Kelly,
openaire   +2 more sources

On edge-colouring indifference graphs

open access: yesTheoretical Computer Science, 1995
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
de Figueiredo, Celina M.H.   +2 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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