Results 141 to 150 of about 90,240,046 (296)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pulmonary Vein Thrombus After Mitral Valve Transcatheter Edge-to-Edge Repair

Methodist DeBakey Cardiovascular Journal
A 76-year-old female with a complicated medical history presented for Watchman (Boston Scientific) placement 2 months after mitral valve transcatheter edge-to-edge repair (TEER).
Aakash Rana, Jack Xu, Jedidiah McMunn, Rupesh Manam   +3 more
doaj   +1 more source

Computed tomography anatomic predictors of outcomes in patients undergoing tricuspid transcatheter edge-to-edge repair.

Journal of cardiovascular computed tomography
AIM To identify anatomical computed tomography (CT) predictors of procedural and clinical outcomes in patients undergoing tricuspid transcatheter edge-to-edge repair (T-TEER).
J. Bartkowiak, Hari Vivekanantham, M. Kassar, C. Dernektsi, Vratika Agarwal, Mark A. Lebehn, Stephan Windecker, N. Brugger, Rebecca T. Hahn, F. Praz   +9 more
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transcatheter Edge-to-Edge Repair in Patients With Complex Tricuspid Valve Anatomy.

JACC: Cardiovascular Interventions
BACKGROUND Untreated severe tricuspid regurgitation (TR) carries a poor prognosis. OBJECTIVES The authors report the 1-year outcomes of transcatheter edge-to-edge repair (TEER) with the TriClip system (Abbott Structural Heart) in patients with complex ...
David H. Adams, Gilbert H. L. Tang, B. Whisenant, S. Kodali, Gagan D. Singh, N. Fam, S. Kar, Matthew J. Price, C. Spies, Jonathan Schwartz, R. Makkar, P. Tadros, A. Asgar, U. Jorde, R. Benza, V. Thourani, Patrick M. McCarthy, R. Bae, Thomas W. Smith, D. Lim, Moody M. Makar, Hursh Naik, M. Latib, M. Sitges, Ralph-Stephan von Bardeleben, P. Lurz, Nadira Hamid, Rebecca T. Hahn, P. Sorajja   +28 more
semanticscholar   +1 more source

Transcatheter mitral valve repair: from edge-to-edge to annuloplasty

, 2018
With more than 35,000 procedures worldwide, percutaneous edge-to-edge repair using MitraClip® is by far the most widely used percutaneous mitral valve intervention for the treatment of mitral regurgitation.
Mehdi Eskandari, Mark J. Monaghan
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Hypoxia Following Mitral Transcatheter Edge-to-Edge Repair

JACC Case Reports
Background Mitral regurgitation (MR) is a common disorder associated with increased risk of morbidity and mortality. Transcatheter edge-to-edge repair (TEER) is a minimally invasive option that is increasingly used in the management of this condition ...
Fajer J. Almoosa, Mamdouh Elsmaan, Michael L. Rigby, S. Mirsadraee, A. Vazir   +4 more
semanticscholar   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source