Results 151 to 160 of about 90,240,046 (296)

Transcatheter edge‐to‐edge repair in papillary muscle injury complicating acute myocardial infarction

ESC Heart Failure
Acute mitral regurgitation (MR) in the setting of myocardial infarction (MI) may be the result of papillary muscle rupture (PMR). This condition is associated with high morbidity and mortality.
D. Haberman, R. Estévez-Loureiro, Andrew Czarnecki, P. Denti, P. Villablanca, K. Spargias, D. Sudarsky, L. Perl, P. Fefer, L. Manevich, G. Masiero, L. Nombela-Franco, L. Poles, B. Caneiro-Queija, Nicolas G. R. Bowers, Davide Schiavi, G. Tarantini, F. Melillo, M. Chrissoheris, Danny Dvir, Francesco Maisano, M. Taramasso, M. Shuvy   +22 more
semanticscholar   +1 more source

Edge-to-Edge Resource Discovery using Metadata Replication

, 2019
Edge computing has been recently introduced as an intermediary between Internet of Things (IoT) deployments and the cloud, providing data or control facilities to participating IoT devices.
Dustdar, Schahram, Tsigkanos, Christos, Avasalcai, Cosmin, Murturi, Ilir   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Safety and Prognostic Implications of Mechanical Circulatory Support‐Assisted Transcatheter Edge‐to‐Edge Repair: The OCEAN‐Mitral Registry

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transcatheter edge‐to‐edge repair of the mitral valve (M‐TEER) has demonstrated promising outcomes for patients with mitral regurgitation who are unsuitable for surgical intervention.
Shuhei Tanaka, Teruhiko Imamura, Ryuichi Ushijima, Makiko Nakamura, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa, Masanori Yamamoto, Shunsuke Kubo, Yuki Izumi, Mike Saji, Masahiko Asami, Yusuke Enta, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Hisao Otsuki, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Gaku Nakazawa, Daisuke Hachinohe, Toshiaki Otsuka, Kentaro Hayashida   +27 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Adaptation of right ventricular function following tricuspid transcatheter edge‐to‐edge repair

ESC Heart Failure
Background The impact of tricuspid transcatheter edge‐to‐edge repair (T‐TEER) on right ventricular (RV) remodelling remains unclear. Objectives This study focused on characterizing changes in RV ejection fraction (RVEF) following T‐TEER and their ...
Sara Bombace, Sebastian Rosch, Anne R. Schöber, Maximilian vonRoeder, Florian Schlotter, Karl‐Philip Rommel, Recha Blessing, Christian Lücke, Matthias Gutberlet, Anna Sannino, Holger Thiele, Philipp Lurz, Karl‐Patrik Kresoja   +12 more
doaj   +1 more source

First Turkish Experience with the PASCAL TEER System

Interventional Cardiology Perspectives
Background: The PASCAL transcatheter edge-to-edge repair (TEER) system was developed for patients with symptomatic severe mitral regurgitation (MR), particularly those at high surgical risk. However, real-world experience with this system remains limited.
Sinem Özbay Özyılmaz, Enes Alıç, Ahmet Huraibat, Mehdi Onaç, Mohamed Niang, Teoman Kılıç, Hakan Uçar   +6 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source