Results 131 to 140 of about 90,240,046 (296)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Echocardiographic Imaging for Transcatheter Tricuspid Edge‐to‐Edge Repair

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Richard Ro, Gilbert H. L. Tang, Karthik Seetharam, Sahil Khera, Samin K. Sharma, Annapoorna S. Kini, Stamatios Lerakis   +6 more
doaj   +1 more source

Echocardiographic Screening for Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation Between Transthoracic and Transesophageal Assessment

Journal of Cardiovascular Development and Disease
Background: In patients with significant mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (M-TEER), assessment of mitral valve (MV) anatomy is essential.
Michela Bonanni, Fausto Pizzino, Giovanni Benedetti, Rosangela Capasso, Rachele Manzo, Giuseppe Iuliano, Giancarlo Trimarchi, Andreina D’Agostino, Umberto Paradossi, Alessia Gimelli, Sergio Berti, Massimiliano Mariani   +11 more
doaj   +1 more source

Combined Impact of Residual Mitral Regurgitation and Gradient After Mitral Valve Transcatheter Edge-to-Edge Repair.

JACC: Cardiovascular Interventions
BACKGROUND Reducing mitral regurgitation (MR) during mitral transcatheter edge-to-edge repair (M-TEER) may come at the cost of increased mitral valve gradient (MVG). The combined impact of residual MR and MVG on clinical outcomes after M-TEER is unknown.
Gagan D. Singh, Matthew J. Price, M. Shuvy, Jason H. Rogers, C. Grasso, F. Bedogni, Federico M. Asch, J. Zamorano, Melody Dong, Kelli Peterman, Evelio Rodriguez, S. Kar, Ralph-Stephan von Bardeleben, Francesco Maisano   +13 more
semanticscholar   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Transcatheter Therapy for the Tricuspid Valve: A Focused Review of Edge-to-Edge Repair and Orthotopic Valve Replacement

Current Cardiology Reports
Patients with severe tricuspid regurgitation (TR) are at risk for significant morbidity and mortality. Transcatheter tricuspid valve interventions (TTVI) may offer patients less invasive treatment alternatives to surgery.
Mahesh V. Madhavan, Vratika Agarwal, Rebecca T. Hahn   +2 more
semanticscholar   +1 more source

Oral History Interview with Jack Edge

The National Museum of the Pacific War presents a monologue with Jack Edge. Edge joined the Navy in 1941. He served aboard the USS Pelias (AS-14). They were conducting submarine overhauls at the Submarine Base where the ship was berthed during the ...
Edge, Jack
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

GeminiOne transcatheter edge-to-edge repair: comparative hemodynamic and biomechanical evaluation

Frontiers in Cardiovascular Medicine
BackgroundTranscatheter edge-to-edge repair (TEER) is frequently used to treat mitral regurgitation (MR) patients. Despite its widely reported efficacy, complications such as single-leaflet device attachment (SLDA) and loss of leaflet insertion (LLI) can
Kai Wang, Dongyang Xu, Dongyang Xu, Bowen Xiao, Zhaoming He, Jianfong Tan, Saibal Kar   +6 more
doaj   +1 more source

Outcomes of transcatheter edge-to-edge repair for atrial functional mitral regurgitation.

EuroIntervention
BACKGROUND The prognostic benefits of transcatheter edge-to-edge repair (TEER) remain unclear in patients with atrial functional mitral regurgitation (AFMR). AIMS We aimed to investigate the clinical outcomes of TEER for patients with AFMR.
Tetsu Tanaka, A. Sugiura, J. Vogelhuber, Can Öztürk, Lukas Böhm, N. Wilde, S. Zimmer, G. Nickenig, M. Weber   +8 more
semanticscholar   +1 more source