Results 181 to 190 of about 898,897 (299)

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Daam-, FMNL-, and mDia-family formins jointly regulate cortical actin dynamics in melanoma cells. [PDF]

Cell Commun Signal
Kaufmann T, Scholz J, Csiszár A, Karger M, Walkenbach M, Rottner K, Merkel R, Curth U, Faix J.   +8 more
europepmc   +1 more source

A Genetic Algorithm Optimising Control Point Placement for Edge Bundling

, 2020
Ryosuke Saga, Tomoki Yoshikawa, Ken Wakita, Ken Sakamoto, Gerald Schaefer, Tomoharu Nakashima   +5 more
openalex   +1 more source

Route‐Aware Edge Bundling for Visualizing Origin‐Destination Trails in Urban Traffic [PDF]

, 2019
Wei Zeng, Qiaomu Shen, Yuzhe Jiang, Alexandru Cristian Telea   +3 more
openalex   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Evolutionary Edge Bundling as a Large-Scale Multi-Objective Optimization Problem: A Comparative Study

Noda, Chihiro, Ryosuke Saga
openalex   +1 more source

Highly‐Time‐Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals

Advanced Science, EarlyView.
Using a novel, aptamer‐based biosensor, here we have performed 20‐s‐resolved, in situ measurements of plasma‐free tryptophan in the jugular veins of live rats (blue). This unprecedented time‐resolution provides insights into the regulation of tryptophan metabolism in live, intact animals.
Yuyang Wu, Chelsea N. Brown, Zeki Duman, Rose Mery Bakestani, Carl M. Kirkpatrick, Joao Hespanha, Tod Kippin, Kevin W. Plaxco   +7 more
wiley   +1 more source

Polydopamine‐Wool Textiles for Sustainable Interfacial Solar Vapor Generation

Advanced Science, EarlyView.
A natural wool textile engineered for high solar absorbance and a fast‐wicking structure serves as a highly efficient, single‐layer system for interfacial solar vapor generation (ISVG). This integrated evaporator seamlessly couples rapid water transport with continuous evaporation. Ultimately, this sustainable photothermal design offers a scalable, eco‐
Kyuin Park, Jintong Gao, Hansadi Jayamaha, Yipu Wang, Mia Bressler, Lenan Zhang, Larissa M. Shepherd   +6 more
wiley   +1 more source

Colloidal Deacetylation of Chitin Nanocrystals Results in Amorphous and Patchy Chitosan Chains. [PDF]

ACS Nano
Jin T, Heermant S, Mianehrow H, Parton TG, Carone A, Nedielkov R, Ogawa Y, Kozuch J, Vignolini S.   +8 more
europepmc   +1 more source

The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune response, maleficent in cancer

, 2020
Elisabeth Schaffner‐Reckinger, Raquel A. C. Machado   +1 more
openalex   +2 more sources