Results 71 to 80 of about 92,928 (333)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
A note on compact and compact circular edge-colorings of graphs
Discrete Mathematics & Theoretical Computer Science, 2008 In the paper we study two variants of edge-coloring of edge-weighted graphs, namely compact edge-coloring and circular compact edge-coloring. First, we discuss relations between these two coloring models.
Dariusz Dereniowski, Adam Nadolski
doaj
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
M2-Edge Colorings Of Cacti And Graph Joins
Discussiones Mathematicae Graph Theory, 2016 An edge coloring φ of a graph G is called an M2-edge coloring if |φ(v)| ≤ 2 for every vertex v of G, where φ(v) is the set of colors of edges incident with v. Let 𝒦2(G) denote the maximum number of colors used in an M2-edge coloring of G.
Czap Július +2 more
doaj +1 more source
On The Local Edge Antimagic Coloring of Corona Product of Path and Cycle
Cauchy: Jurnal Matematika Murni dan Aplikasi, 2019 Let be a nontrivial and connected graph of vertex set and edge set . A bijection is called a local edge antimagic labeling if for any two adjacent edges and , where for . Thus, the local edge antimagic labeling induces a proper edge coloring of G if
Siti Aisyah +4 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Majority Edge-Colorings of Graphs
The Electronic Journal of Combinatorics, 2023 We propose the notion of a majority $k$-edge-coloring of a graph $G$, which is an edge-coloring of $G$ with $k$ colors such that, for every vertex $u$ of $G$, at most half the edges of $G$ incident with $u$ have the same color. We show the best possible results that every graph of minimum degree at least $2$ has a majority $4$-edge-coloring, and that ...
Bock, Felix +5 more
openaire +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source