Results 31 to 40 of about 2,462 (240)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mode-shell correspondence, a unifying phase space theory in topological physics - Part I: Chiral number of zero-modes

SciPost Physics
We propose a theory, that we call the mode-shell correspondence, which relates the topological zero-modes localised in phase space to a shell invariant defined on the surface forming a shell enclosing these zero-modes.
Lucien Jezequel, Pierre Delplace
doaj   +1 more source

Numerical survey of predicted peeling response in edge localised mode mitigated and suppressed phases on ASDEX upgrade [PDF]

Plasma Physics and Controlled Fusion, 2019
Abstract Using the MARS-F linear MHD code (Liu et al 2000 Phys. Plasmas 57 , 3681), a numerical survey of the plasma response to applied resonant magnetic perturbations in ASDEX Upgrade edge localised mode (ELM ...
D A Ryan, M Dunne, A Kirk, S Saarelma, W Suttrop, C Ham, Y Q Liu, M Willensdorfer   +7 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Quasi-continuous exhaust operational space

Nuclear Fusion
The IPED predictive pedestal code has been used to determine the critical gradients for the onset of 1) separatrix ballooning modes and 2) global peeling-ballooning modes as a function of plasma shaping.
M. Dunne, M. Faitsch, L. Radovanovic, E. Wolfrum, the ASDEX Upgrade Team   +4 more
doaj   +1 more source

Heat flux analysis of Type-I ELM impact on a sloped, protruding surface in the JET bulk tungsten divertor

Nuclear Materials and Energy, 2018
Tungsten (W) melting due to transient power loads, for example those delivered by edge localised modes (ELMs), is a major concern for next step fusion devices.
J. Gaspar, J.W. Coenen, Y. Corre, R. Dejarnac, M. Firdaouss, F. Clairet, J. Gunn, D. Iglesias, M. Komm, K. Krieger, G. Matthews, R.A. Pitts, S. Silburn   +12 more
doaj   +1 more source

Non-linear magnetohydrodynamic simulations of edge localised mode triggering via vertical position oscillations in ITER [PDF]

Nuclear Fusion, 2018
Magnetic triggering of edge localized modes (ELMs) in Ohmic H-mode plasmas was first reported in the TCV tokamak (Degeling et al 2003 Plasma Phys. Control. Fusion 45 1637). This method, showing reliable locking of the ELM frequency to an imposed axisymmetric vertical plasma oscillation, was also demonstrated in the ITER-relevant type-I ELM regime in ...
Artola, Francisco Javier, Huijsmans, A., Hoelzl, M., Beyer, P., Loarte, A., Gribov, Y.   +5 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Assessing the merits of resonant magnetic perturbations with different toroidal mode numbers for controlling edge localised modes

Nuclear Fusion, 2014
An increase in ELM frequency has been demonstrated in MAST by applying resonant magnetic perturbations (RMPs) with toroidal mode number, nRMP = 2, 3, 4, 6. It has been observed that the mitigated ELM frequency increases with the amplitude of the applied field provided it is above a critical threshold.
Chapman, I.T., Kirk, A., Akers, R.J., Ham, C.J., Harrison, J.R., Hawke, J., Liu, Y.Q., McClements, K.G., Pamela, S., Saarelma, S., Scannell, R., Thornton, A.J., Team, MAST   +12 more
openaire   +2 more sources