Results 41 to 50 of about 2,462 (240)

A high-repetition rate edge localised mode replication system for the Magnum-PSI and Pilot-PSI linear devices [PDF]

Plasma Physics and Controlled Fusion, 2014
A high-power edge-localized mode (ELM) striking onto divertor components presents one of the strongest lifetime and performance challenges for plasma facing components in future fusion reactors. A high-repetition-rate ELM replication system has been constructed and was commissioned at the Magnum-PSI linear device to investigate the synergy between ...
Morgan, T.W., de Kruif, T.M., van der Meiden, H.J., van den Berg, M.A., Scholten, J., Melissen, W., Krijger, B.J. M., Bardin, S., De Temmerman, G.   +8 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effect of symmetry-breaking on the MHD edge stability limit of tokamak plasmas

Nuclear Fusion
We demonstrate for the first time that symmetry-breaking in tokamak plasmas reduces the window of stable edge operational space, leading to a lower achievable edge pressure gradient.
J. Puchmayr, M. Dunne, E. Strumberger, M. Willensdorfer, H. Zohm, F. Hindenlang, the ASDEX Upgrade Team   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

2D heat flux in ASDEX Upgrade L-Mode with magnetic perturbation

Nuclear Materials and Energy, 2017
Power exhaust is one of the major challenges for a future fusion device like ITER. Future devices are foreseen to operate in a regime that exhibits periodic outbursts of particles and energy, so called edge localised modes (ELMs).
M. Faitsch, B. Sieglin, T. Eich, A. Herrmann, W. Suttrop   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Local plasma shape modification to facilitate access to quasi continuous exhaust (QCE) regime

Nuclear Fusion
The effects of a poloidally localized bulge at outer midplane are investigated with regards to the stability of ideal MHD peeling-ballooning modes (PBMs) and $n = \infty$ ballooning modes.
S. Saarelma, S. Bakes, L. Frassinetti, STEP Team   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The core–edge integrated neon-seeded scenario in deuterium–tritium at JET

Nuclear Fusion
This paper reports the first experiment carried out in deuterium–tritium addressing the integration of a radiative divertor for heat-load control with good confinement. Neon seeding was carried out for the first time in a D–T plasma as part of the second
C. Giroud, I.S. Carvalho, S. Brezinsek, A. Huber, D. Keeling, J. Mailloux, R.A. Pitts, E. Lerche, R. Henriques, J. Hillesheim, K. Lawson, M. Marin, E. Pawelec, M. Sos, H.J. Sun, M. Tomes, S. Aleiferis, A. Bleasdale, M. Brix, A. Boboc, J. Bernardo, P. Carvalho, I. Coffey, S. Henderson, D.B. King, F. Rimini, M. Maslov, E. Alessi, T. Craciunescu, M. Fontana, J.M. Fontdecaba, L. Garzotti, Z. Ghani, L. Horvath, I. Jepu, J. Karhunen, D. Kos, E. Litherland-Smith, A. Meigs, S. Menmuir, R.B. Morales, S. Nowak, E. Peluso, T. Pereira, V. Parail, G. Petravich, G. Pucella, P. Puglia, D. Refy, S. Scully, M. Sertoli, S. Silburn, D. Taylor, B. Thomas, A. Tookey, Ž. Štancar, G. Szepesi, B. Viola, A. Widdowson, E. de la Luna, JET Contributors   +60 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source