Results 91 to 100 of about 189,025 (287)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Exact lattice-model calculation of boundary modes for Weyl semimetals and graphene
New Journal of Physics, 2020 We provide an exact analytical technique to obtain within a lattice model the wave functions of the edge states in zigzag- and bearded-edge graphene, as well as of the Fermi-arc surface states in Weyl semimetals described by a minimal bulk model.
Vardan Kaladzhyan +3 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Persistent current in 2D topological superconductors
Scientific Reports, 2017 A junction between two boundaries of a topological superconductor (TSC), mediated by localized edge modes of Majorana fermions, is investigated. The tunneling of fermions across the junction depends on the magnetic flux.
Igor N. Karnaukhov
doaj +1 more source
Bifurcation behaviour of resonant magnetic perturbation control of edge localized modes in tokamaks: nonlinear simulation results. [PDF]
Philos Trans A Math Phys Eng Sci, 2023 Thyagaraja A, Sen A, Chandra D.
europepmc +1 more source
Discrete solitons and nonlinear surface modes in semi-infinite waveguide arrays
, 2006 We discuss the formation of self-trapped localized states near the edge of a semi-infinite array of nonlinear waveguides. We study a crossover from nonlinear surface states to discrete solitons by analyzing the families of odd and even modes centered at ...
Christodoulides +10 more
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2000 We present a method of finding approximate analytical solutions for the spectra and eigenvectors of collective modes in a two-dimensional system of interacting bosons subjected to a linear external potential or the potential of a special form $u(x,y)=\mu
B.D. Esry +32 more
core +1 more source