Results 71 to 80 of about 2,473,071 (281)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Edge localized magnetosonic eigenmodes in the ion cyclotron frequency range

, 2003
Edge localized magnetosonic modes are analyzed in toroidal plasmas. For low and medium high toroidal mode numbers they are found to propagate poloidally around the plasma.
Laxåbäck, Martin,, T. Hellsten, M. Laxåback, Hellsten, Torbjörn,   +3 more
core   +1 more source

Taming harmful bursts and heat flux in high-confinement tokamak plasmas

Nature Communications
A major challenge in tokamak fusion research is first-wall erosion caused by steady heat loads and sudden energy bursts known as edge-localized modes. Divertor detachment reduces steady-state heat flux, while resonant magnetic perturbations can suppress ...
Q. M. Hu, H. Q. Wang, M. Navarro, H. H. Wang, D. Eldon, S. Gu, X. X. Ma, H. Frerichs, F. Scotti, L. Wang, R. S. Wilcox, T. M. Wilks, A. Bortolon, L. Ceelen, F. Effenberg, X. Z. Gong, M. N. Jia, S. K. Kim, C. J. Lasnier, A. W. Leonard, K. D. Li, N. C. Logan, Q. Ma, R. Maingi, L. Y. Meng, A. L. Moser, T. H. Osborne, C. Paz-Soldan, M. W. Shafer, Y. W. Sun, S. M. Yang, C. Ye   +31 more
doaj   +1 more source

Experimental investigation of ELM-like transient heat loads on plasma-facing materials using runaway electrons

Nuclear Materials and Energy
Edge-localized modes (ELMs) and runaway electrons (REs) are among the most critical transient heat sources responsible for degradation of plasma-facing materials (PFMs) in tokamaks. Small-scale tokamaks, such as Damavand, provide a practical platform for
Ali Masoudi, Davoud Iraji, Chapar Rasouli   +2 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Plasmonic band edge effects on the transmission properties of metal gratings

AIP Advances, 2011
We present a detailed analysis of the optical properties of one-dimensional arrays of slits in metal films. Although enhanced transmission windows are dominated by Fabry-Perot cavity modes localized inside the slits, the periodicity introduces surface ...
D. de Ceglia, M. A. Vincenti, M. Scalora, N. Akozbek, M. J. Bloemer   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Edge localized modes and the pedestal: A model based on coupled peeling-ballooning modes

, 2002
A model based on magnetohydrodynamic (MHD) stability of the tokamak plasma edge region is presented, which describes characteristics of edge localized modes (ELMs) and the pedestal.
Lao, L.L., Wilson, H.R., Osborne, T.H., Ferron, J.R., Snyder, P.B., Turnbull, A.D., Leonard, A.W., A. D. Turnbull, D. Mossessian, J. R. Ferron, M. Murakami, L. L. Lao, P. B. Snyder, A. W. Leonard, H. R. Wilson, T. H. Osborne, X. Q. Xu   +16 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source