Results 81 to 90 of about 2,473,071 (281)

Bifurcation behaviour of resonant magnetic perturbation control of edge localized modes in tokamaks: nonlinear simulation results. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Thyagaraja A, Sen A, Chandra D.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exact lattice-model calculation of boundary modes for Weyl semimetals and graphene

New Journal of Physics, 2020
We provide an exact analytical technique to obtain within a lattice model the wave functions of the edge states in zigzag- and bearded-edge graphene, as well as of the Fermi-arc surface states in Weyl semimetals described by a minimal bulk model.
Vardan Kaladzhyan, Sarah Pinon, Jens H Bardarson, Cristina Bena   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Impurity accumulation and edge localized mode(ELM).

Kakuyūgō kenkyū, 1988
The effect of the impurity ions on the L/ H and H/ L transitions in tokamaks is discussed. It is found that the impurity accumulation can trigger the transition from the H-mode to the L-mode. The relation with ELM is also discussed.
Ohkawa, Tihiro, Itoh, Kimitaka, Itoh, Sanae-I.   +2 more
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Edge Localized Mode Control in TCV

, 2012
The Tokamak concept, based on magnetic confinement of a hydrogen plasma, is one of today's most promising paths to energy production by nuclear fusion. The experimental scenarios leading to the largest fusion rate are based on a high confinement plasma regime, the H-mode, in which the energy and particle confinement are enhanced by a transport barrier ...
openaire   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A new type of resonant magnetic perturbation for controlling edge localized modes

Nuclear Fusion
A new type of resonant magnetic perturbation (RMP), generated by helical coils, is proposed for controlling the edge localized mode (ELM) in H-mode tokamak plasmas. The helical coil optimization utilizes the MARS-F code (Liu et al 2000 Phys.
Xu Yang, Yueqiang Liu, Xuan Sun, Wei Xu, Li Li, Yuling He, Guoliang Xia, Hanqing Hu, Lina Zhou   +8 more
doaj   +1 more source