Results 81 to 90 of about 189,025 (287)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Non-ideal MHD analysis of pedestal scans of AUG and JET

Nuclear Fusion
The extended MHD code CASTOR3D is used to perform the MHD stability analysis of predictive pedestal scans of standard ASDEX Upgrade and JET-ILW scenarios.
F. Stefanelli, M.G. Dunne, J. Puchmayr, H. Zohm   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Edge electron states for quasi-one-dimensional organic conductors in the magnetic-field-induced spin-density-wave phases

, 2001
We develop a microscopic picture of the electron states localized at the edges perpendicular to the chains in the Bechgaard salts in the quantum Hall regime. In a magnetic-field-induced spin-density-wave state (FISDW) characterized by an integer N, there
A. Virosztek, B. I. Halperin, C. Honerkamp, C. L. Kane, D. P. Druist, D. Poilblanc, G. E. Volovik, G. E. Volovik, G. Ernst, G. Montambaux, G. Montambaux, Hyok-Jon Kwon, J. M. Kikkawa, J. T. Chalker, K. Sengupta, L. Balents, M. J. Naughton, M. Stone, R. C. Ashoori, R. V. Chamberlin, S. A. Brazovskii, S. A. Brazovskii, S. G. Davison, S. Uji, T. Ishiguro, T. Senthil, U. M. Scheven, V. M. Yakovenko, V. M. Yakovenko, V. M. Yakovenko, Victor M. Yakovenko, X. G. Wen, Y. Hatsugai, Y. Hatsugai, Y. Hatsugai   +34 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Taming harmful bursts and heat flux in high-confinement tokamak plasmas

Nature Communications
A major challenge in tokamak fusion research is first-wall erosion caused by steady heat loads and sudden energy bursts known as edge-localized modes. Divertor detachment reduces steady-state heat flux, while resonant magnetic perturbations can suppress ...
Q. M. Hu, H. Q. Wang, M. Navarro, H. H. Wang, D. Eldon, S. Gu, X. X. Ma, H. Frerichs, F. Scotti, L. Wang, R. S. Wilcox, T. M. Wilks, A. Bortolon, L. Ceelen, F. Effenberg, X. Z. Gong, M. N. Jia, S. K. Kim, C. J. Lasnier, A. W. Leonard, K. D. Li, N. C. Logan, Q. Ma, R. Maingi, L. Y. Meng, A. L. Moser, T. H. Osborne, C. Paz-Soldan, M. W. Shafer, Y. W. Sun, S. M. Yang, C. Ye   +31 more
doaj   +1 more source

Plasmonic band edge effects on the transmission properties of metal gratings

AIP Advances, 2011
We present a detailed analysis of the optical properties of one-dimensional arrays of slits in metal films. Although enhanced transmission windows are dominated by Fabry-Perot cavity modes localized inside the slits, the periodicity introduces surface ...
D. de Ceglia, M. A. Vincenti, M. Scalora, N. Akozbek, M. J. Bloemer   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Edge Localized Mode Control in TCV

, 2012
The Tokamak concept, based on magnetic confinement of a hydrogen plasma, is one of today's most promising paths to energy production by nuclear fusion. The experimental scenarios leading to the largest fusion rate are based on a high confinement plasma regime, the H-mode, in which the energy and particle confinement are enhanced by a transport barrier ...
openaire   +1 more source

Topological Superconducting Phases of Weakly Coupled Quantum Wires

, 2014
An array of quantum wires is a natural starting point in realizing two-dimensional topological phases. We study a system of weakly coupled quantum wires with Rashba spin-orbit coupling, proximity coupled to a conventional s-wave superconductor. A variety
Berg, Erez, Oreg, Yuval, Seroussi, Inbar
core   +1 more source