Results 61 to 70 of about 254,578 (267)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Vertex-Edge Resolvability of Some Wheel-Related Graphs

open access: yesJournal of Mathematics, 2021
A vertex w∈VH distinguishes (or resolves) two elements (edges or vertices) a,z∈VH∪EH if dw,a≠dw,z. A set Wm of vertices in a nontrivial connected graph H is said to be a mixed resolving set for H if every two different elements (edges and vertices) of H ...
Bao-Hua Xing   +4 more
doaj   +1 more source

Embedding relatively hyperbolic groups in products of trees

open access: yes, 2013
We show that a relatively hyperbolic group quasi-isometrically embeds in a product of finitely many trees if the peripheral subgroups do, and we provide an estimate on the minimal number of trees needed. Applying our result to the case of 3-manifolds, we
Alessandro Sisto   +4 more
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On the Constant Edge Resolvability of Some Unicyclic and Multicyclic Graphs

open access: yesJournal of Mathematics, 2022
Assume that G=VG,EG is a connected graph. For a set of vertices WE⊆VG, two edges g1,g2∈EG are distinguished by a vertex x1∈WE, if dx1,g1≠dx1,g2. WE is termed edge metric generator for G if any vertex of WE distinguishes every two arbitrarily distinct ...
Dalal Alrowaili   +5 more
doaj   +1 more source

Exact Computation of a Manifold Metric, via Lipschitz Embeddings and Shortest Paths on a Graph

open access: yes, 2020
Data-sensitive metrics adapt distances locally based the density of data points with the goal of aligning distances and some notion of similarity. In this paper, we give the first exact algorithm for computing a data-sensitive metric called the nearest ...
Chu, Timothy   +2 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Edge metric dimension of some classes of circulant graphs

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020
Let G = (V (G), E(G)) be a connected graph and x, y ∈ V (G), d(x, y) = min{ length of x − y path } and for e ∈ E(G), d(x, e) = min{d(x, a), d(x, b)}, where e = ab. A vertex x distinguishes two edges e1 and e2, if d(e1, x) ≠ d(e2, x). Let WE = {w1, w2, . .
Ahsan Muhammad   +2 more
doaj   +1 more source

Hearing Delzant polytopes from the equivariant spectrum

open access: yes, 2012
Let M^{2n} be a symplectic toric manifold with a fixed T^n-action and with a toric K\"ahler metric g. Abreu asked whether the spectrum of the Laplace operator $\Delta_g$ on $\mathcal{C}^\infty(M)$ determines the moment polytope of M, and hence by Delzant'
Dryden, Emily B.   +2 more
core   +1 more source

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