Results 61 to 70 of about 22,588 (272)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Vertex-Edge Resolvability of Some Wheel-Related Graphs

Journal of Mathematics, 2021
A vertex w∈VH distinguishes (or resolves) two elements (edges or vertices) a,z∈VH∪EH if dw,a≠dw,z. A set Wm of vertices in a nontrivial connected graph H is said to be a mixed resolving set for H if every two different elements (edges and vertices) of H ...
Bao-Hua Xing, Sunny Kumar Sharma, Vijay Kumar Bhat, Hassan Raza, Jia-Bao Liu   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Vertex and edge resolvability of some drug structures

Results in Chemistry
Distance-based parameters are crucial in studying drug structures as they help in uniquely identifying and characterizing the molecular structure through the analysis of graph representations, thereby aiding in the understanding of molecular properties ...
Ayesha Andalib Kiran, Hani Shaker, Muhammad Faisal Nadeem, Bahreselam Sielu Abraha   +3 more
doaj   +1 more source

On the Constant Edge Resolvability of Some Unicyclic and Multicyclic Graphs

Journal of Mathematics, 2022
Assume that G=VG,EG is a connected graph. For a set of vertices WE⊆VG, two edges g1,g2∈EG are distinguished by a vertex x1∈WE, if dx1,g1≠dx1,g2. WE is termed edge metric generator for G if any vertex of WE distinguishes every two arbitrarily distinct ...
Dalal Alrowaili, Zohaib Zahid, Imran Siddique, Sohail Zafar, Muhammad Ahsan, Muhammad Sarwar Sindhu   +5 more
doaj   +1 more source

Vertices, edges, distances and metric dimension in graphs

Electronic Notes in Discrete Mathematics, 2016
Abstract Given a connected graph G = ( V , E ) , a set of vertices S ⊂ V is an edge metric generator for G , if any two edges of G are identified by S by mean of distances to the vertices in S . Moreover, in a natural way, S is a mixed metric generator, if any two elements of G (vertices or edges) are identified by S by
openaire   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Edge metric dimension of some classes of circulant graphs

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020
Let G = (V (G), E(G)) be a connected graph and x, y ∈ V (G), d(x, y) = min{ length of x − y path } and for e ∈ E(G), d(x, e) = min{d(x, a), d(x, b)}, where e = ab. A vertex x distinguishes two edges e1 and e2, if d(e1, x) ≠ d(e2, x). Let WE = {w1, w2, . .
Ahsan Muhammad, Zahid Zohaib, Zafar Sohail   +2 more
doaj   +1 more source