Results 71 to 80 of about 254,578 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Vertex and edge resolvability of some drug structures
Results in ChemistryDistance-based parameters are crucial in studying drug structures as they help in uniquely identifying and characterizing the molecular structure through the analysis of graph representations, thereby aiding in the understanding of molecular properties ...
Ayesha Andalib Kiran +3 more
doaj +1 more source
DIMENSI METRIK GRAF HASIL OPERASI JEMBATAN DARI CATERPILLAR HOMOGEN DAN POT BUNGA DIPERUMUM
Majalah Ilmiah Matematika dan Statistika, 2022 The metric dimension is a concept that has many applications, such as robotic navigation. This concept will distinguish each vertex of a graph based on some vertices. The distinguishing vertices are called the basis of the graph.
Gusma Hidayanti +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The edge partition dimension of graphs [PDF]
Discrete Mathematics Letters, 2023 Dorota Kuziak +3 more
doaj +1 more source
A remark on the metric dimension in Riemannian manifolds of constant curvature [PDF]
AUT Journal of Mathematics and ComputingWe compute the metric dimension of Riemannian manifolds of constant curvature. We define the edge weghited metric dimension of the geodesic graphs in Riemannian manifolds and we show that each complete geodesic graph $G=(V,E)$ embedded in a Riemannian ...
Shiva Heidarkhani Gilani +2 more
doaj +1 more source
On the Edge Resolvability of Double Generalized Petersen Graphs
Journal of Mathematics, 2022 For a connected graph G=VG,EG, let v∈VG be a vertex and e=uw ∈EG be an edge. The distance between the vertex v and the edge e is given by dGe,v=mindGu,v,dGw,v. A vertex w∈VG distinguishes two edges e1,e2∈EG if dGw,e1≠dGw,e2.
Tanveer Iqbal +4 more
doaj +1 more source
Emergent Space-Time via a Geometric Renormalization Method
, 2016 We present a purely geometric renormalization scheme for metric spaces (including uncolored graphs), which consists of a coarse graining and a rescaling operation on such spaces. The coarse graining is based on the concept of quasi-isometry, which yields
Rastgoo, Saeed, Requardt, Manfred
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source