Results 91 to 100 of about 2,320,114 (270)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Metric Dimension of a Diagonal Family of Generalized Hamming Graphs [PDF]
, 2022 Classical Hamming graphs are Cartesian products of complete graphs, and two vertices are adjacent if they differ in exactly one coordinate. Motivated by connections to unitary Cayley graphs, we consider a generalization where two vertices are adjacent if
Foster-Greenwood, Briana, Uhl, Christine
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 1970 The metric dimension of a compact metric space is defined here as the order of growth of the exponential metric entropy of the space. The metric dimension depends on the metric, but is always bounded below by the topological dimension. Moreover, there is
Reese T. Prosser
core +1 more source
Fault-tolerant basis and fault-tolerant edge basis of three classes of French windmill graphs
Ain Shams Engineering JournalA resolving set is a subset of vertices that uniquely identifies every vertex based on distances. A fault-tolerant resolving set maintains this condition under any single-vertex removal, and the minimum size of such a set is the fault-tolerant metric ...
S. Prabhu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dimension Distortion by Sobolev Mappings in Foliated Metric Spaces [PDF]
, 2013 We quantify the extent to which a supercritical Sobolev mapping can increase the dimension of subsets of its domain, in the setting of metric measure spaces supporting a Poincaré inequality. We show that the set of mappings that distort the dimensions of
Tyson, Jeremy T. +5 more
core +3 more sources
A valent-based metric framework for analyzing intuitionistic fuzzy graphs in uncertain environments
Ain Shams Engineering JournalThis paper introduces a new notion of distance in intuitionistic fuzzy graphs, termed the Valent distance, which incorporates the degrees (valences) of both vertices and edges.
J. Komathi, D. Meiyappan, K. Anitha
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source