Results 91 to 100 of about 254,578 (267)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Fault-tolerant basis and fault-tolerant edge basis of three classes of French windmill graphs

Ain Shams Engineering Journal
A resolving set is a subset of vertices that uniquely identifies every vertex based on distances. A fault-tolerant resolving set maintains this condition under any single-vertex removal, and the minimum size of such a set is the fault-tolerant metric ...
S. Prabhu, P. Angelin Kiruba, A. Davoodi, Paul Manuel   +3 more
doaj   +1 more source

On metric dimension of edge comb product of vertex-transitive graphs [PDF]

Transactions on Combinatorics
Suppose finite graph $G$ is simple, undirected and connected. If $W$ is an ordered set of the vertices such that $|W| = k$, the representation of a vertex $v$ is an ordered $k$-tuple consisting distances of vertex $v$ with every vertices in $W$. The set $
Tita Maryati, Dindin Sobiruddin, Maifalinda Fatra, Fawwaz Hadiputra   +3 more
doaj   +1 more source

The dominant metric dimension of graphs

Heliyon, 2020
The G be a connected graph with vertex set V(G) and edge set E(G). A subset S⊆V(G) is called a dominating set of G if for every vertex x in V(G)∖S, there exists at least one vertex u in S such that x is adjacent to u.
Liliek Susilowati, Imroatus Sa'adah, Ratna Zaidatul Fauziyyah, Ahmad Erfanian, Slamin   +4 more
doaj   +1 more source

Non-Perturbative Gravity and the Spin of the Lattice Graviton

, 2004
The lattice formulation of quantum gravity provides a natural framework in which non-perturbative properties of the ground state can be studied in detail.
A. M. Polyakov, B. Mandelbrot, B. Nienhuis, C. Itzykson, G. Parisi, G. Parisi, G. ’t Hooft, H. Aoki, H. W. Hamber, H. W. Hamber, Herbert W. Hamber, J. Ambjorn, J. Cheeger, J. Cheeger, J. Julve, J. Lense, J. Zinn-Justin, J. Zinn-Justin, J. A. Wheeler, J. C. Le Guillou, K. G. Wilson, L. Fadeev, L. Fadeev, M. Aizenman, M. Aizenman, M. Roc̆ek, R. Arnowitt, R. P. Feynman, R. P. Feynman, Ruth M. Williams, S. Deser, S. Weinberg, S. W. Hawking, T. Regge, T. D. Lee   +34 more
core   +1 more source

Edge Metric Dimension on Some Families of Tree

Journal of Physics: Conference Series, 2019
Metric Dimension as a graph invariant has various applications in real life. One of the metric dimension application is for the navigation system in transportation. In this Paper, we continue to develop the study of edge metric dimension. Let G = (V, E) be a connected graph with v ∈ V and e = uw ∈ E.
R. Adawiyah, null Dafik, R. Alfarisi, R. M. Prihandini, I. H. Agustin   +4 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Asymptotic Dimension of Graphs of Groups and One Relator Groups

, 2020
We prove a new inequality for the asymptotic dimension of HNN-extensions. We deduce that the asymptotic dimension of every finitely generated one relator group is at most two, confirming a conjecture of A.Dranishnikov. As further corollaries we calculate
Tselekidis, Panagiotis
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source