Results 101 to 110 of about 238,609 (287)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Metric dimension and diameter of graphs [PDF]
, 2020 : A graph G = (V, E) is a non-empty collection of vertices and edges, where V is the vertex set, E the edge set and |V (G)| is the order of a graph. The diameter, D, of a graph is the maximum distance between any two vertices.
Rivett-Carnac, Emily J.
core
Fault-tolerant basis and fault-tolerant edge basis of three classes of French windmill graphs
Ain Shams Engineering JournalA resolving set is a subset of vertices that uniquely identifies every vertex based on distances. A fault-tolerant resolving set maintains this condition under any single-vertex removal, and the minimum size of such a set is the fault-tolerant metric ...
S. Prabhu +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The dominant metric dimension of graphs
Heliyon, 2020 The G be a connected graph with vertex set V(G) and edge set E(G). A subset S⊆V(G) is called a dominating set of G if for every vertex x in V(G)∖S, there exists at least one vertex u in S such that x is adjacent to u.
Liliek Susilowati +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On the vertices belonging to all edge metric bases [PDF]
An edge metric basis of a connected graph G is a smallest possible set of vertices S of G satisfying the following: for any two edges e, f of G there is a vertex s ∈ S such that the distances from s to e and f differ.
González Yero, Ismael +3 more
core +1 more source
The Edge Metric Dimension of the Comb Product of a Cycle and a Graph with a Dominant Vertex
Electronic Journal of Graph Theory and ApplicationsIn this paper, we determine the edge metric dimension of the comb product of a cycle graph and a simple graph containing a dominant vertex. This result generalizes previous findings on the edge metric dimension of the comb product of a cycle and a ...
Abdilla Nurul Azisah Mn +3 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source