Results 111 to 120 of about 2,320,114 (270)

METRIC DIMENSION OF GRAPHS WITH SEQUENTIAL PENDANT EDGE EXTENSION

Reliability: Theory & Applications
The metric dimension of a graph measures the smallest number of vertices (landmarks) needed so that every vertex in the graph can be uniquely identified by its distances to these landmarks.
Ajendra Kumar, B.S. Rawat, Kirti Chauhan
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Local fractional metric dimension of rotationally symmetric planar graphs arisen from planar chorded cycles [PDF]

, 2023
In this paper, a new family of rotationally symmetric planar graphs is described based on an edge coalescence of planar chorded cycles. Their local fractional metric dimension is established for those ones arisen from chorded cycles of order up to six ...
Falcón Ganfornina, Raúl Manuel, Mahmood, Muhammad Khalid, Ali, Shahbaz   +2 more
core  

On the edge metric dimension for the random graph

, 2016
Let $G(V, E)$ be a connected simple undirected graph. In this paper we prove that the edge metric dimension (introduced by Kelenc, Tratnik and Yero) of the Erdős-Rényi random graph $G(n, p)$ is given by: $$\textrm{edim}(G(n, p)) = (1 + o(1))\frac{4\log(n)}{\log(1/q)},$$ where $q = 1 - 2p(1-p)^2(2-p)$.
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

On the metric dimension of converging sequences [PDF]

, 1993
summary:In the paper, some kind of independence between upper metric dimension and natural order of converging sequences is shown --- for any sequence converging to zero there is a greater sequence with an arbitrary ($\leqslant 1$) upper dimension.
Žáčik, Tibor, Mišík, Ladislav, Jr.
core  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Fault-Tolerant Metric Dimension and Applications: Zero-Divisor Graph of Upper Triangular Matrices

Mathematics
Graph invariants play a crucial role in understanding the structural and combinatorial characteristics of graphs. The fault-tolerant metric dimension, as a significant graph invariant, finds applications in diverse areas such as robust network ...
Latif Abdelmalek Hanna, Maryam M. Alkandari, Vijay Kumar Bhat   +2 more
doaj   +1 more source