Results 41 to 50 of about 2,944,639 (323)

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase

bioRxiv
DNA base editors could enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently.
Huawei Tong, Haoqiang Wang, Nana Liu, Guoling Li, Yingsi Zhou, Danni Wu, Yun Li, Ming Jin, Xuchen Wang, Hengbin Li, Yinghui Wei, Yuan Yuan, Linyu Shi, Xuan Yao, Hui Yang   +14 more
semanticscholar   +1 more source

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

Nature Communications, 2020
CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single nucleotide mutations in research or therapeutic settings. Efficient base editing requires cellular exposure to levels of base editors that can be difficult to attain in ...
Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, H. Valley, Xiao-ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, H. Bihler, M. Mense, Z. Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue   +16 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Söz uçar yazı kalır [PDF]

, 2004
Taha Toros Arşivi, Dosya No: 40-Ahmet Hamdi Tanpınarİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN ...
Asiltürk, Baki
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Valproic acid induced hyperammonemic encephalopathy: A case report [PDF]

, 2018
Valproic acid (VPA) is commonly used drug to treat variety of anticonvulsant and mood stabilizer in psychiatric and neurologic cases. It is thought to be a safe drug with a large therapeutic aspect..Uncommonly, hyperammonemia can be progressed by the ...
Apa, Ferda, Ateþci, F.Ç., Varma, G.S.
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Disiplinlerarası araştırma ve eğitim [PDF]

, 2007
Bu Bölümde disiplinlerarası yaklaşım ve küreselleşme ve getirdiği sorunlar arasındaki ilişki irdelenmekte; yönetim ve ekonomideki değişimlerin disiplinlerarası araştırma ve eğitim için yarattığı talep üzerinde durulmakta; üniversite paradigmasındaki ...
Ulusoy, Gunduz, Ulusoy, Gündüz
core  

The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald.

ACS Nano, 2019
Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the memory of ACS Nano associate editor Prof. Dr. Helmuth Möhwald, we discuss the developments and applications that are to come
Shuang Zhao, F. Caruso, L. Dähne, G. Decher, B. D. De Geest, Jinchen Fan, N. Feliu, Y. Gogotsi, P. Hammond, M. Hersam, A. Khademhosseini, N. Kotov, S. Leporatti, Yan Li, F. Lisdat, L. Liz‐Marzán, S. Moya, P. Mulvaney, A. Rogach, Sathi Roy, D. Shchukin, A. Skirtach, M. Stevens, G. Sukhorukov, P. Weiss, Zhao Yue, Dingcheng Zhu, W. Parak   +27 more
semanticscholar   +1 more source