Results 91 to 100 of about 1,791,230 (278)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Deriving Compact Test Suites for Telecommunication Software Using Distance Metrics

Journal of Communications Software and Systems, 2009
This paper proposes a string edit distance based test selection method to generate compact test sets for telecommunications software. Following the results of previous research, a trace in a test set is considered to be redundant if its edit distance ...
Gábor Kovács, Gábor Árpád Németh, Zoltán Pap, Mahadevan Subramaniam   +3 more
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Tree edit distance for leaf-labelled trees on free leafset and its comparison with frequent subsplit dissimilarity and popular distance measures

BMC Bioinformatics, 2011
Background This paper is devoted to distance measures for leaf-labelled trees on free leafset. A leaf-labelled tree is a data structure which is a special type of a tree where only leaves (terminal) nodes are labelled.
Walczak Krzysztof, Koperwas Jakub
doaj   +1 more source

Dynamic Dyck and Tree Edit Distance: Decompositions and Reductions to String Edit Distance*

2025 IEEE 66th Annual Symposium on Foundations of Computer Science (FOCS)
We present the first dynamic algorithms for Dyck and tree edit distances with subpolynomial update times. Dyck edit distance measures how far a parenthesis string is from a well-parenthesized expression, while tree edit distance quantifies the minimum number of node insertions, deletions, and substitutions required to transform one rooted, ordered ...
Das, D., Gilbert, J., Hajiaghayi, M., Kociumaka, T., Saha, B.   +4 more
openaire   +4 more sources

Greedy Graph Edit Distance

, 2015
In pattern recognition and data mining applications, where the underlying data is characterized by complex structural relationships, graphs are often used as a formalism for object representation. Yet, the high representational power and flexibility of graphs is accompanied by a significant increase of the complexity of many algorithms.
Kaspar Riesen, Miquel Ferrer, Rolf Dornberger, Horst Bunke   +3 more
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Computational Models of Symbolic Rhythm Similarity: Correlation with Human Judgments [PDF]

Analytical Approaches to World Music, 2011
A novel approach to describing rhythmic relationships in music is introduced by means of three experiments designed to test computational measures of symbolic rhythm similarity against human judgments.
Toussaint, Godfried T., Campbell, Malcolm, Brown, Naor   +2 more
doaj