Results 71 to 80 of about 270,614 (275)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Application of Genetic Algorithms for Finding Edit Distance between Process Models
Моделирование и анализ информационных систем, 2018 Finding graph-edit distance (graph similarity) is an important task in many computer science areas, such as image analysis, machine learning, chemicalinformatics.
Anna A. Kalenkova, Danil A. Kolesnikov
doaj +1 more source
Approximating Edit Distance Efficiently [PDF]
45th Annual IEEE Symposium on Foundations of Computer Science, 2004 Edit distance has been extensively studied for the past several years. Nevertheless, no linear-time algorithm is known to compute the edit distance between two strings, or even to approximate it to within a modest factor. Furthermore, for various natural algorithmic problems such as low-distortion embeddings into normed spaces, approximate nearest ...
Z. Bar-Yossef +3 more
openaire +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Linear space string correction algorithm using the Damerau-Levenshtein distance
BMC Bioinformatics, 2020 Background The Damerau-Levenshtein (DL) distance metric has been widely used in the biological science. It tries to identify the similar region of DNA,RNA and protein sequences by transforming one sequence to the another using the substitution, insertion,
Chunchun Zhao, Sartaj Sahni
doaj +1 more source
Convex Graph Invariant Relaxations For Graph Edit Distance [PDF]
, 2019 The edit distance between two graphs is a widely used measure of similarity that evaluates the smallest number of vertex and edge deletions/insertions required to transform one graph to another.
Candogan, Utkan Onur +1 more
core +1 more source
Journal of Discrete Algorithms, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kim, Sung-Ryul, Park, Kunsoo
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source