Results 111 to 120 of about 4,250,670 (346)

Improving prime editing with an endogenous small RNA-binding protein

Nature
Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3′ ends of CRISPR–Cas guide RNAs1.
Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar, Carl C Ward, Sébastien Levesque, Yangwode Jing, Danny Simpson, Anqi Zhao, Hui Li, Weihao Yan, L. Goudy, Ralf Schmidt, Sabrina C Solley, Luke A. Gilbert, Michelle M. Chan, Daniel E. Bauer, Alex Marson, Lance R. Parsons, Britt Adamson   +18 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Film Editing as Women’s Work: Ėsfir’ Shub, Elizaveta Svilova, and the Culture of Soviet Montage

Apparatus. Film, Media and Digital Cultures of Central and Eastern Europe, 2018
This study takes as its point of departure the history and contributions of two Soviet editors/directors – Ėsfir’ Shub and Elizaveta Svilova – in order to make visible what has largely remained invisible: film editing as “women’s” work.
Lilya Kaganovsky
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Syntezator mowy jako narzędzie wspierające pracę tłumacza

Między Oryginałem a Przekładem, 2014
The speech synthesiser as a tool supporting the job of the translator The present paper discusses the speech synthesis technology and its potential use as a tool supporting translators. The growing popularity, improving quality and ubiquity of speech
Wojciech Figiel
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

DiffEditor: Boosting Accuracy and Flexibility on Diffusion-Based Image Editing [PDF]

Computer Vision and Pattern Recognition
Large-scale Text-to-Image (T2I) diffusion models have revolutionized image generation over the last few years. Although owning diverse and high-quality generation capabilities, translating these abilities to fine-grained Image editing remains challenging.
Chong Mou, Xintao Wang, Jie Song, Ying Shan, Jian Zhang   +4 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

How films convey meaning through alternating structures (with an illustrative analysis of The Sunbeam)

Frontiers in Communication
Films and texts differ in terms of their possible logical structures and freedom of presentation on an output medium. While texts can be structured at any depth, the capabilities for structuring films are generally limited. In the presentation of textual
Karl-Heinrich Schmidt
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source