Results 51 to 60 of about 2,341,500 (267)

Carry on editing [PDF]

open access: yesBritish Medical Bulletin, 2018
Genome editing facilitates alterations to DNA, large or subtle, in a precise fashion. In its most popular form it uses the programmable endonuclease system, CRISPR/Cas9. Edits can be made to any genome, including the human genome. This raises the possibility of genome editing in human embryos in both a research and reproductive context.All reports of ...
openaire   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Planting the Seeds of Artistic Subversiveness in À Bout De Souffle: Godard’s Trailblazing Cinematic Language

open access: yesStudies in Logic, Grammar and Rhetoric, 2020
The following article frames a particular case study: Jean-Luc Godard’s À bout de souffle (1960), referenced in the paper with its American title, Breathless. Foraging through the dense and sophisticated thicket of narrative, visual and textual features,
Kendall James
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Stekliannyi Glaz (The Glass Eye) and Karmen – The Actress, Editor and Director Lilia Brik

open access: yesApparatus. Film, Media and Digital Cultures of Central and Eastern Europe, 2018
In this work I hope to illustrate how female authorship emerged within the circle of the Soviet avant-garde, using the example of Lilia Brik’s (1891–1978) little-known film Stekliannyi glaz, released in 1929.
Adelheid Heftberger
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Authoring from the Shadows: Creativity and the Film Archive in The Autobiography of Nicolae Ceaușescu

open access: yesApparatus. Film, Media and Digital Cultures of Central and Eastern Europe, 2018
Dana Bunescu is one of the most recognized and appreciated Romanian film editors, a key figure in the landscape of New Romanian cinema. This essay will address Bunescu’s artistic contribution as an essential part of the collective film author.
Raluca Iacob
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Film Editing as Women’s Work: Ėsfir’ Shub, Elizaveta Svilova, and the Culture of Soviet Montage

open access: yesApparatus. Film, Media and Digital Cultures of Central and Eastern Europe, 2018
This study takes as its point of departure the history and contributions of two Soviet editors/directors – Ėsfir’ Shub and Elizaveta Svilova – in order to make visible what has largely remained invisible: film editing as “women’s” work.
Lilya Kaganovsky
doaj   +1 more source

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