Results 51 to 60 of about 2,685,499 (252)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Fast Vertex Merging for Cluster Editing
, 2021 FPT algorithms for cluster editing are relatively successful in practice, however there is still the need for a fast weighted graph data-structure that allows merging vertices and deleting edges while keeping track of a lower bound.
Holten, Lucas (author)
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Editing Medical Data Records with a Natural Language Interface [PDF]
, 2007 Power R, Pietsch C. Editing Medical Data Records with a Natural Language Interface. Presented at the Accepted for presentation at the 2nd International Symposium on Languages in Biology and Medicine (LBM) 2007, Matrix, Biopolis, Singapore.Background ...
Pietsch, Christian ; https://orcid.org/ +1 more
core
Editing-defective MeV are selected in Raji cells.
, 2019 Chromatograms of dideoxy-sequencing over the P gene editing site from viruses passaged on Raji or JVM-2 cells. Cell type used and passage numbers are indicated above the chromatograms.
Christian K. Pfaller (6029036) +2 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2018 This footage was filmed in August 2014 at London Film School in Covent Garden, London, United Kingdom.Former BBC film editors Dawn Trotman and Oliver White demonstrated the use of Steenbeck and Acmade PicSync film editing equipment, while breaking down ...
Nick Hall (4554379) +2 more
core +1 more source