Results 261 to 270 of about 7,393,185 (358)

Revealing Dynamic Ion Transport in Tailorable Carbon Nano‐Skyscraper Electrodes

Advanced Science, EarlyView.
A 3D carbon nanotube electrode reveals how ions and electrons prioritize rapid transport over the shortest paths during charging. By creating a uniformly interconnected porous network, researchers improved electrode efficiency, surpassing traditional localized and gradient designs.
Jiye Li, Xiaoyang Zheng, Luting Zhu, Yihang Yao, Sisi Yan, Lang Wang, Jing He, Chen Zhao, Ziqian Zhou, Liaoyong Wen   +9 more
wiley   +1 more source

Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education. [PDF]

iScience
Ciubotariu II, Kobayashi T, Neely CJ, Tawia Hagan DF, Ewusi-Mensah D, Van Vactor D, Whipple EC, Camacho E, Ghosh G, Lamb HM, Owusu-Frimpong I, Alltop J, Romano JD, Kelly K, Rogers LS, Morales L, Seibel M, Rao R, Bekka S, Mills WT, Casadevall A, Bosch G.   +21 more
europepmc   +1 more source

PlantGPT: An Arabidopsis‐Based Intelligent Agent that Answers Questions about Plant Functional Genomics

Advanced Science, EarlyView.
PlantGPT integrates 60 000+ plant research articles with Arabidopsis phenotype‐gene data through retrieval‐augmented generation and fine‐tuning of Llama3‐8B. This open‐source, specialized AI system outperforms general large language models in plant gene‐phenotype relationships, establishing a new paradigm for functional genomics research and molecular ...
Ruixiang Zhang, Yu Wang, Weiyang Yang, Jun Wen, Weizhi Liu, Shipeng Zhi, Guangzhou Li, Nan Chai, Jiaqi Huang, Yongyao Xie, Xianrong Xie, Letian Chen, Miao Gu, Yao‐Guang Liu, Qinlong Zhu   +14 more
wiley   +1 more source

Sequence‐ and Docking‐Site‐Dependent Contributions to Multi‐Site Phosphorylation of an Intrinsically Disordered MAPK Substrate

Advanced Science, EarlyView.
Real‐time NMR spectroscopy is used to study JNK1‐dependent phosphorylation of the intrinsically disordered substrate JIP1, revealing eleven phosphosites with distinct phosphorylation efficiencies. The site‐specific phosphorylation rates are shown to be determined by both the sequence position of the phosphosites relative to the two kinase docking site ...
Thibault Orand, Elise Delaforge, Marion Chenal, Maud Tengo, Torsten Herrmann, Juan Cortés, Pau Bernadó, Malene Ringkjøbing Jensen   +7 more
wiley   +1 more source

To the Editor: In Expectation of a More Evidence-Informed Perspective on Emergency Medicine Education. [PDF]

J Grad Med Educ
Chukwuanu KA, Burkhartsmeier C, Krausz C.   +2 more
europepmc   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

The Role of Registered Dietitians in Cancer Palliative Care: Responsibilities, Challenges, and Interdisciplinary Collaboration-A Cross-Sectional Survey. [PDF]

Curr Oncol
Koshimoto S, Amano K, Mori N, Imai A, Sasaki M, Miyajima M, Takeuchi T.   +6 more
europepmc   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

Implementing the Promotion in Place Model of Competency-Based Time-Variable Graduate Medical Education in Pathology. [PDF]

J Grad Med Educ
Martinez-Lage M, Goldhamer MEJ, Pusic MV, Branda JA, Weinstein DF, Black-Schaffer WS, Co JPT.   +6 more
europepmc   +1 more source

Personalized Medication for Chronic Diseases Using Multimodal Data‐Driven Chain‐of‐Decisions

Advanced Science, EarlyView.
A MDD‐CoD is proposed for personalized chronic disease medication. The framework simulates clinical chain‐of‐decisions through three linked deep learning tasks, validated on multi‐center datasets (3 hospitals, 4 diseases), demonstrating enhanced generalization and interpretability in cross‐disease applications.
Xiaoli Chu, Yiheng Ye, Siqiao Tang, Miaoru Han, Guowei Wang, Shuai Lin, Bingzhen Sun, Qingchun Huang, Yan Zhang, Xiaodong Chu, Kun Bao   +10 more
wiley   +1 more source