Results 21 to 30 of about 400,775 (265)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

“Ako ʻĒ Ka Hale A Paʻa”: Mentoring for Kānaka Futures through Hilinehu Educational Leadership Advancement

Journal Committed to Social Change on Race and Ethnicity
In this article, we explore our experiences as Kānaka faculty mentors in Hilinehu Educational Leadership Advancement (HELA), a federally-funded grant through the Native Hawaiian Education Program (NHEP) supporting Kānaka graduate students in the field of
Erin Kahunawaikaʻala Wright, Nicole Alia Salis Reyes, Julie Kaomea, Eōmailani K. Kukahiko, Stacy Kealanahele Prellberg, Jennifer Māhealani Ah Sing Quirk, A. Kuʻulei Serna   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Examining Service-Learning in a Graduate Physical Education Teacher Education Course

Journal of the Scholarship of Teaching and Learning, 2012
This study was designed to explore the impact of service-learning on graduate physical education teacher education students. Social-Cognitive Theory (Bandura, 1986; 1999) served as the framework to examine graduate student’s experiences in a service ...
Karen S. Meaney, Jeff M. Housman, Arnoldo Cavazos, Michelle L. Wilcox   +3 more
doaj   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Entrustable Professional Activities for Pathology

Academic Pathology, 2017
Competency-based medical education has evolved over the past decades to include the Accreditation Council for Graduate Medical Education Accreditation System of resident evaluation based on the Milestones project.
Cindy B. McCloskey MD, Ronald E. Domen MD, Richard M. Conran MD, PhD, JD, Robert D. Hoffman MD, PhD, Miriam D. Post MD, Mark D. Brissette MD, Dita A. Gratzinger MD, PhD, Patricia M. Raciti MD, David A. Cohen MD, Cory A. Roberts MD, Amyn M. Rojiani MD, PhD, Christina S. Kong MD, Jo Elle G. Peterson MD, Kristen Johnson PhD, Sue Plath MA, Suzanne Zein-Eldin Powell MD   +15 more
doaj   +1 more source

Curriculum Development of Educational Technology Graduate Degree with a focus on Special Education in Iran [PDF]

پژوهش در نظام‌های آموزشی, 2018
The aim of this study was to develop a graduate degree in educational technology curriculum with a focus on special education in Iran. The method of research was descriptive-analytic and compatible with Brady method.
Esmaeil Zaraii Zavaraki
doaj   +1 more source

Disrupting the Narrative on Recruiting Graduate Students of Color in Counselor Education

Teaching and Supervision in Counseling, 2021
The voices of students of color are largely absent in the literature on graduate student recruitment in counselor education. The existing literature focuses on university personnel and can portray a deficit perspective of students of color.
Carlos P. Hipolito-Delgado , Diane Estrada , Marina Garcia   +2 more
doaj   +1 more source