Results 91 to 100 of about 21,060,376 (300)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Mechanical modelling and simulation of thrust force in drilling process in GFRP composite laminates: A novel system dynamics approach

Cogent Engineering, 2019
Drilling is a salient machining process employed in assembling the components and structures made from polymer composites. Influence of various drilling process parameters on the drilling process has been identified and controlled to maintain the ...
B. R. N. Murthy, Vijay G.S, S. Narayan, Nithesh Naik, Nilakshman Sooriyaperakasam, Aravind Karthik, Revati Borkhade   +6 more
doaj   +1 more source

Learning roadmaps for Higher Education [PDF]

, 2007
An integrated platform for the support of teaching activities as been developed and deployed at the Aveiro Norte Polytechnic School of the University of Aveiro.
Duarte, A. Manuel de Oliveira, Oliveira, Miguel, Serrano, J. Artur   +2 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Psychosocial Burden Among Informal Caregivers of Adult Cancer Patients Attending a Tertiary Care Cancer Center in Coastal South India

SAGE Open, 2019
Cancer is the most dreaded and chronic disease with its treatment lasting almost lifelong with an uncertainty of cure. This not only adversely affects the quality of life among patients but also poses a psychosocial burden among family members ...
Bhaskaran Unnikrishnan, Priya Rathi, P. U. Prakash Saxena, Apoorva Aggarwal, Shashank Shekhar, Sarthak Bansal, B. Venkat Naidu, Sarath Menon   +7 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Clinical Evaluation of Kinesio Taping Outcomes in Stage II Cellulite: A Pilot Study

Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija
Background. Cellulite is a common aesthetic condition linked to alterations in subcutaneous fat and dermal connective tissue, with possible impairment of microcirculation and lymphatic drainage. Kinesio taping (KT) is used in physiotherapy, but evidence
Laura Žalienė, Mercedes Šulcaitė-Vasiljeva, Simona Kasperavičiūtė, Jurgita Boltutienė, Simona Urbonienė, Daiva Stančaitytė , Gražina Šniepienė, Vitalija Gerikienė   +7 more
doaj   +1 more source

The demand for higher education in the Netherlands 1950-'99 [PDF]

This paper investigates the role of economic factors in the university enrollment decision for the post-war period in the Netherlands. We include those factors standing at the heart of the idea that education is an investment.
Erik Canton, Frank de Jong
core  

Higher education institutions : subject profile [PDF]

, 2011
"This briefing provides an overview of Higher Education Institutions in Scotland.
Berry, Kate
core