Results 131 to 140 of about 831,801 (314)

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

Challenges and Advances in Medical Education Conference & Summer Institute

Canadian Medical Education Journal, 2010
CALL FOR PAPERS Deadline: May 15, 2010   3   3 rd International Congress in Medical Education Sponsored by Medical Education Research Centre, Università Ambrosiana International Graduate Medical Education Program Medical Education Research Unit ...
Claudio Violato
doaj  

Facile Synthesis of Nanolayered Manganese Oxide for the Efficient and Selective Removal of Strontium(II) from Nuclear Wastewater

Advanced Science, EarlyView.
A novel nanolayered manganese oxide material (Na‐NLMO) is prepared using a rapid and straightforward method for efficient adsorption of Sr(II) in both simulated waste liquid and natural water systems. Its excellent adsorption performance of Na‐NLMO could be attributed to the accessible layered structure and negatively charged framework.
Fan Wang, Qi Zheng, Wenya Tai, Qiang Wu, Xinglei Li, Yehuizi Wu, Ningchao Zheng, Shunyan Ning, Deqian Zeng, Hiroshi Watabe, Yan Wu, Hai Li, Yuezhou Wei, Xiangbiao Yin   +13 more
wiley   +1 more source

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

Advanced Science, EarlyView.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen, Yuhan Gao, Kaiyuan Huo, Zhaofan Jin, Wenchao Wang, Xingjie Zan, Yanlong Liu, Limeng Zhu, Jianfeng Yang   +8 more
wiley   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model

Advanced Science, EarlyView.
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis, Elena Capitanini, Karen Kira, Claudia Dell'Amico, Jun Takahashi, Marco Onorati, Fabian Raudzus, Vittoria Raffa   +7 more
wiley   +1 more source

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

The State of Mastery Learning in Pediatric Graduate Medical Education: A Scoping Review

Advances in Medical Education and Practice
Michaela Mills-Rudy,1 Megan Thorvilson,1 Cynthia Chelf,2 Stephanie Mavis3 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; 2Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 3Department of Pediatric and ...
Mills-Rudy M, Thorvilson M, Chelf C, Mavis S   +3 more
doaj  

Tailored Crystallization Dynamics for Efficient and Stable DMSO‐Free Tin Perovskite Solar Cells

Advanced Science, EarlyView.
In this work, the authors investigated the crystallization process of tin perovskites in a DMSO‐free solvent system using in situ PL technique. The authors discovered that a synergistic approach effectively facilitates the formation of high‐quality DMSO‐free tin perovskite films by modulating the emergence of crystallites and the aggregation process ...
Shengnan Zuo, Alexander Tarasov, Lennart Frohloff, Karunanantharajah Prashanthan, Florian Ruske, Mailis Lounasvuori, Chiara Frasca, André Dallmann, Fengshuo Zu, Florian Mathies, Florian Scheler, Noor Titan Putri Hartono, Guixiang Li, Jinzhao Li, Maxim Simmonds, Wenhui Li, Norbert Koch, Steve Albrecht, Meng Li, Eva Unger, Mahmoud Hussein Aldanmasy, Artem Musiienko, Antonio Abate   +22 more
wiley   +1 more source

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Advanced Science, EarlyView.
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng   +13 more
wiley   +1 more source