Results 161 to 170 of about 1,165,379 (311)

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

open access: yesAdvanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan   +11 more
wiley   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

open access: yesAdvanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh   +11 more
wiley   +1 more source

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

open access: yesAdvanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao   +20 more
wiley   +1 more source

Neutrophil/Lymphocyte Ratio as a Predictive Biomarker of NIV Failure in AECOPD: The Unveiled Facts [Letter]

open access: yesInternational Journal of COPD
Dipasri Bhattacharya,1 Antonio M Esquinas,2 Mohanchandra Mandal3 1Department of Anaesthesiology, Pain Medicine and Critical Care, R.G.Kar Medical College & Hospital, Kolkata, West Bengal, India; 2Critical Care Specialist and Staff Physician ...
Bhattacharya D, Esquinas AM, Mandal M
doaj  

The Nagoya University and the University of Adelaide Joint PhD Degree Program in Medicine - A Program of Opportunity. [PDF]

open access: yesAdv Med Educ Pract
Aleksic B   +9 more
europepmc   +1 more source

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

open access: yesAdvanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy