Results 161 to 170 of about 1,203,531 (305)

Record‐High Performance Hyperfluorescent OLEDs Achieved via Electronic Structure Control of Chlorine‐Diversified MR‐TADF Emitters

open access: yesAdvanced Science, EarlyView.
A late‐stage diversification strategy for the benchmark MR‐TADF emitter ω‐DABNA enables precise electronic structure control via chlorine‐activated functionalization. The resulting derivatives achieve tunable emission from 523 to 533 nm with record‐high EQE1000 up to 34.0% and excellent color purity (CIEy = 0.70–0.73), establishing a versatile platform
Taehwan Lee   +7 more
wiley   +1 more source

An Analysis of Graduate Medical Education Program Coordinator Job Descriptions. [PDF]

open access: yesJ Grad Med Educ
Anderson L   +5 more
europepmc   +1 more source

Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix

open access: yesAdvanced Science, EarlyView.
A modular in vitro glioblastoma multiforme (GBM) model combining patient‐derived glioma stem‐like cells (GSC) organoid with an engineered extracellular matrix (eECM) and endothelial co‐culture enhances differentiation and GBM associated gene expression.
Autumn McManis   +7 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan   +11 more
wiley   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

open access: yesAdvanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou   +9 more
wiley   +1 more source

Neutrophil/Lymphocyte Ratio as a Predictive Biomarker of NIV Failure in AECOPD: The Unveiled Facts [Letter]

open access: yesInternational Journal of COPD
Dipasri Bhattacharya,1 Antonio M Esquinas,2 Mohanchandra Mandal3 1Department of Anaesthesiology, Pain Medicine and Critical Care, R.G.Kar Medical College & Hospital, Kolkata, West Bengal, India; 2Critical Care Specialist and Staff Physician ...
Bhattacharya D, Esquinas AM, Mandal M
doaj  

Molecularly Engineered Phenoxazinone‐Skeleton Cascade‐Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis‐Mediated Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
A series of Fe2+/viscosity cascade‐activated NIR fluorescence probes (NP1–5) are synthesized, and NP3 is selected for its optimal properties. To verify application of NP3 in ferroptosis intervention in PD, PQR NPs, is constructed by NP3 and quercetin self‐assembling.
Lixia Guo   +11 more
wiley   +1 more source

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