Results 111 to 120 of about 1,732,170 (258)

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Factores relacionados con el rendimiento académico en la asignatura Morfofisiología Humana IV, del Programa Nacional de Formación de Medicina Integral Comunitaria Factors related with the academic performance in the matter Human Morpho-physiology IV, of the National Program of Formation of Community Integral Medicine

Revista Médica Electrónica, 2011
Se realizó un estudio de investigación, con el objetivo de caracterizar el rendimiento académico del grupo de estudiantes del Programa Nacional de Formación en Medicina Integral Comunitaria, durante el desarrollo de la asignatura Morfofisiología Humana ...
Caridad Martínez Pedroso, Yamilka Eulalia Leiva Cubeñas, Esther G Báez Pérez, José Fernández Morín   +3 more
doaj  

Impact of the COVID-19 pandemic on medical education: Medical students' knowledge, attitudes, and practices regarding electronic learning. [PDF]

PLoS One, 2020
Alsoufi A, Alsuyihili A, Msherghi A, Elhadi A, Atiyah H, Ashini A, Ashwieb A, Ghula M, Ben Hasan H, Abudabuos S, Alameen H, Abokhdhir T, Anaiba M, Nagib T, Shuwayyah A, Benothman R, Arrefae G, Alkhwayildi A, Alhadi A, Zaid A, Elhadi M.   +20 more
europepmc   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Educational actions to deal with student diversity in Dentistry in the context of COVID-19

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020
Background: proposing tasks and educational actions to deal with student diversity can contribute to the reorganization and the quality of the teaching-learning process in the major of dentistry, given the challenge that COVID-19 represents.Objective: to
Taimí Santos-Velázquez, Sara Elena Panizo-Bruzón   +1 more
doaj  

A Mixed Methods Approach to Assess the Impact of an Interprofessional Education Medical Error Simulation. [PDF]

Am J Pharm Educ, 2020
Marshall C, Van Der Volgen J, Lombardo N, Hamasu C, Cardell E, Blumenthal DK.   +5 more
europepmc   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Factores asociados a la culminación del proyecto de investigación requerido para optar el título de especialista en una universidad peruana

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos: Determinar la frecuencia y los factores asociados a la culminación del proyecto de investigación requerido para optar el título de especialista en una universidad peruana. Materiales y métodos. Se realizó un estudio transversal.
Ray Ticse, Oscar Pamo, Frine Samalvides, Tania Quispe   +3 more
doaj   +2 more sources

Historia de los programas de formación y titulación de médicos especialistas en el Perú

Revista Peruana de Medicina Experimental y Salud Pública
En el presente artículo se hace referencia histórica a las disposiciones legales de reconocimiento de la formación y titulación de los médicos especialistas en el Perú mediante programas de estudios universitarios, previstos desde el año 1928, que ...
Zuño Burstein Alva
doaj