Results 111 to 120 of about 4,323,358 (286)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Sistema de actividades metodológicas con enfoque de competencia didáctica para profesores de Farmacología I, de la carrera de Medicina. Matanzas System of methodological activities with an approach of didactical competence for professors of Pharmacology I in the career of Medicine in Matanzas

Revista Médica Electrónica, 2011
Se asumió como enfoque el de las competencias docentes del profesor universitario en el contexto de la universalización. Se utilizaron métodos teóricos, que posibilitaron el estudio en relación con la concepción de la competencia didáctica que se ...
Beatriz Romero Fernández, Nieves E Garriga Alfonso, Rita R Martínez Pichardo   +2 more
doaj  

Seeking Equity; Pathway Programs in Liaison Committee on Medical Education Medical Schools for Minoritized Students. [PDF]

J Med Educ Curric Dev, 2023
Ogunyemi D, Westermeyer C, Eghbali M, Patel P, Struble S, Arogyaswamy S, Teixeira A, Raval N, Gentry M, Lee T, Arabian S.   +10 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Differences between Type 2 Diabetes Mellitus and Obesity Management: Medical, Social, and Public Health Perspectives [PDF]

Diabetes & Metabolism Journal
Obesity and type 2 diabetes mellitus (T2DM) are among the most urgent global public health challenges, yet differ markedly in recognition and management across medical, social, infrastructure, and policy domains.
Soo Lim, Ga Eun Nam, Arya M. Sharma
doaj   +1 more source

Interprofessional Education: Medical Students Create a Cadaver Lab Workshop for Nursing Students at a Neutral Cost. [PDF]

Cureus, 2021
Pruitt W, Parianos M, Faraci N, Heaner D, Topping D, Burr J.   +5 more
europepmc   +1 more source

Leveraging Social Media to Promote EvidenceBased Continuing Medical Education [PDF]

, 2017
Importance New dissemination methods are needed to engage physicians in evidence-based continuing medical education (CME). Objective To examine the effectiveness of social media in engaging physicians in non-industry-sponsored CME.
Flynn, Simone, Hebert, Paul, Jordan, William B., Keyhan, Salomeh, Korenstein, Deborah, Ryan, Mark   +5 more
core   +4 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Academic performance in Molecular Biology during the implementation of the curricular plan D at the Affiliated College of Medical Sciences of Puerto Padre

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019
Background: the implementation of the plan D in the medical curriculum led to the emergence of the discipline of Biological Bases of Medicine which includes the subject of Molecular Biology.Objective: to describe the results of the academic achievement ...
Rebeca Guevara-González, Dayne Mariana Álvarez-Ramírez, José Ramón Martínez-Pérez, Idalia de la Cruz Peña-Pérez, Yunelsy Ortíz-Cabrera   +4 more
doaj