Results 161 to 170 of about 4,493,322 (286)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Evaluación por competencias en la educación médica

open access: yesRevista Peruana de Medicina Experimental y Salud Pública
En la actualidad, se considera al modelo curricular por competencias el más apropiado para la educación médica. Mucho se ha escrito sobre este modelo curricular, sin embargo, un aspecto crucial es la evaluación del desarrollo de las competencias, este es
Denisse Champin
doaj  

Research in medical education - chances and challenges : international conference, 20th - 22nd May 2009, Heidelberg ; congress abstracts [PDF]

open access: yes, 2011
Research in Medical Education Chances and Challenges International Conference <2009, Heidelberg>
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Titulación por tesis en escuelas de medicina de Lima, 2011: características, motivaciones y percepciones

open access: yesRevista Peruana de Medicina Experimental y Salud Pública
Se encuestó a los médicos titulados por tesis de las siete escuelas de Medicina de Lima en el 2011 de las siete escuelas de Medicina de Lima para conocer las características del proceso de titulación por tesis, sus motivaciones y sus percepciones sobre ...
Christian R Mejia   +2 more
doaj  

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