Results 61 to 70 of about 4,323,358 (286)
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu+11 more
wiley +1 more source
Sistemas de microscopía virtual: análisis y perspectivas
Desde finales del siglo XX la microscopía se ha venido transformando, incluyendo nuevos recursos que mejoran y perfeccionan su práctica. Entre ellos se destaca el microscopio virtual, la sinergia entre disciplinas como la patología, la histología, la ...
Diana Marín, Eduardo Romero
doaj +1 more source
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau+11 more
wiley +1 more source
Medical education and the 21st century [PDF]
Medical education at both the undergraduate and postgraduate levels has been undergoing continuous changes in the last 40 years. The author why future Maltese doctors should continue with their medical education and have the opportunity to specialize in ...
Fenech, Frederick F.
core
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit+19 more
wiley +1 more source
Prerequisite for Enhancing Student Learning Outcomes in Medical Education
Anyone achieving a grade of “A” has performed at a very good level. The label, “triple A”, is sometimes used to distinguish those who are particularly outstanding.
C B Hazlett
doaj
Fundamento: a tres años de instaurada la asignatura Sistemas cardiovascular, respiratorio, digestivo y renal (CARDIREN), del plan de estudio D, es posible caracterizar el rendimiento académico de los estudiantes en la misma.Objetivo: caracterizar el ...
Yunelsy Ortiz-Cabrera+4 more
doaj
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson+11 more
wiley +1 more source