Results 61 to 70 of about 1,732,170 (258)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Estrategia metodológica para capacitar al tutor de la Vanguardia Mario Muñoz. Una experiencia camagüeyana Methodological strategy to qualify tutors of the vanguards movement Mario Muñoz. A Camagüeyan experience

Humanidades Médicas, 2012
La insuficiente preparación teórica-metodológica de los tutores de la Vanguardia Mario Muñoz Monroy se identificó como el problema científico abordado en la tesis de maestría: Estrategia metodológica para capacitar al tutor de la “Vanguardia Mario ...
Ismet Batista Hernández, Sonia Socarrás Sánchez, Alberto Bujardón Mendoza   +2 more
doaj  

Elements of a didactic program to teach an optional course on COVID-19 in dentistry

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020
Background: the pandemic caused by COVID-19 demands that future dental professionals acquire the necessary knowledge, always keeping in mind the student diversity, allowing them to contribute to the prevention and control of the disease.Objective: to ...
Taimí Santos-Velázquez
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Strengths of the medicine degree for the formation of the professional life project in times of COVID-19

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2021
Background: the complex epidemiological situation that exists worldwide, caused by COVID-19, results in changes in teaching processes.Objective: to elaborate theoretical-methodological considerations on the strengths of the medicine degree for the ...
Solvey del-Río-Marichal, Yamila Cuenca-Arbella   +1 more
doaj  

Medical Education [PDF]

Nature, 1922
n ...
openaire   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Perceptions and understanding of organ donation among medical undergraduates in Southeastern Nigeria [PDF]

Scripta Medica
Background/Aim: Organ donation continues to be acknowledged globally as the preferred treatment for individuals with end-stage organ diseases. So far, it is one of the greatest advances of modern science and has resulted in many patients getting a new ...
Njelita Ifeoma Anne, Akabuike Josephat Chukwudi, Eyisi Ifeanyi Gabriel, Nwachukwu Chinyerem Cynthia, Ezenyeaku Chijioke Amara, Nonye Juliana Ezeonyejiaku, Mbomson Onyinye Paschaline   +6 more
doaj   +1 more source