Results 51 to 60 of about 12,065,332 (289)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Application of “Internet+” in the Ageing Adaptation of Elderly People with Disabilities at Home
Journal of Mathematics, 2021 This paper focuses on the role of the Internet in empowering social work to intervene in ageing-in-place services for the disabled elderly in terms of time, space, and resources.
Huang Juan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Typical report: Newsletter of the Division of Special Education [Vol. 3, No. 2]
, 1970 "February 1970.""A report to cover all areas of special education and to serve as a clearing house through which pertinent information is disseminated to local school administrators and special education personnel.
Kansas. State Department of Education. Division of Special Education.
core +1 more source
(Special) Education is Political; (Special) Education is Social Justice
Journal of Critical Thought and Praxis, 2020 Though treated as neutral and apolitical by schools, teachers, scholars, and administrators, special education is fraught with inequality and loaded language, and can function to segregate and disempower students. The debate over who is worthy of education–and what kind of education–is intimately tied to conceptions of dis/ability.
Lilly Padia, Rachel E Traxler
openaire +2 more sources
, 2008 application/pdfState Performance Plan (SPP) and Annual Report (APR) Special Education Services (july 31, 2008) State Performance Plan (SPP) and Annual Report (APR) Special Education Services (November, 2008) State Performance Plan (SPP) and Annual ...
Kansas. State Department of Education. Special Education Services.
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
A Typical report: Newsletter of the Special Education Section [Vol. 5, No. 2]
, 1972 "March, 1972.""A report to cover all areas of special education and to serve as a clearing house through which pertinent information is disseminated to local school administrators and special education personnel.
Kansas. Special Education Administration Section.
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source