Results 71 to 80 of about 282,488 (288)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Competency-based veterinary education: an integrative approach to learning and assessment in the clinical workplace

Perspectives on Medical Education, 2015
When graduating from veterinary school, veterinary professionals must be ready to enter the complex veterinary profession. Therefore, one of the major responsibilities of any veterinary school is to develop training programmes that support students ...
Harold G. J. Bok
doaj   +1 more source

How can veterinarians be interesting partners for organic dairy farmers? French farmers’ point of views [PDF]

, 2017
Organic dairy farmers must live up to the organic goal of ‘good health’ in respect the organic principles and regulation. Veterinarians could be the organic dairy farmers’ expected sparring partners in reaching this goal but have found difficulties to ...
Bareille, Nathalie, Duval, Julie, Fourichon, Christine, Madouasse, Aurélien, Vaarst, Mette   +4 more
core   +3 more sources

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

The future of flourishing in veterinary medicine: a systems-informed positive psychology approach in veterinary education

Frontiers in Veterinary Science
Individuals in the veterinary profession are experiencing significant mental health and wellbeing challenges. A holistic view of wellbeing, which encompasses both physical and mental health, underscores their interconnected nature.
Virginia K. Corrigan, Rebecca L. Newman, Philip Richmond, Elizabeth B. Strand, Josh M. Vaisman   +4 more
doaj   +1 more source

Student experiences and perceptions of compulsory research projects: a veterinary perspective [PDF]

, 2017
Background Although research underpins clinical work, many students training to be clinicians are not inherently interested in developing research skills.
Baxter Magolda, Braun, Bruner, Bruner, Bryman, Burgoyne, Cleland, Dale, Davis, Deci, Fraser, Funston, Garcia, Greenhalgh, Heath, Hunter, Husman, Ivankova, Krueger, Laidlaw, McManus, Miles, Murray, Park, Piaget, Rosol, Russell, Ryan, Sackett, Selbourne, Stubbs, Todd, Vygotsky, Weller, Wood, Wood   +35 more
core   +2 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Evaluation of livestock farmers’ knowledge, attitudes and practices regarding the use of veterinary vaccines in Southwest Ethiopia

Veterinary Medicine and Science, 2023
Background The utilization of veterinary vaccines plays a vital role in preventing and managing animal diseases. However, the success of vaccination programmes relies on livestock farmers’ understanding, perspectives and behaviours regarding their ...
Dereje Tulu Robi, Ararsa Bogale, Shiferaw Temteme, Melkam Aleme, Beksisa Urge   +4 more
doaj   +1 more source