Results 191 to 200 of about 17,225,283 (320)

Evaluation of a person-centred, group-based, culturally appropriate diabetes education model for migrants with type 2 diabetes: a qualitative study. [PDF]

Prim Health Care Res Dev
Hadziabdic E, Hjelm K.
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Global research agenda for medical education regulation: findings from a nominal group consensus exercise. [PDF]

BMJ Glob Health
Bollela VR, Burch V, Dharanipragada K, Frambach J, Grant J, Haruna-Cooper L, Kabiri H, Kelly J, Martimianakis MA, Menezes da Silva F, Mohsen L, Nicholson JG, Rashid MA, Rojas D, Tackett S, Whitehead CR, Wondimagegn D, Zaini R.   +17 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Fall 2011, IA ALUMNI: Where in the world is. . . ? [PDF]

, 2011
Center for International Education
core   +6 more sources

Designing a virtual learning framework in medical education: lessons learned from the COVID-19 pandemic. [PDF]

BMC Med Educ
Allameh SF, Zolfaghari M, Alizadeh M, MehrPooya M, Emadi N, Bahramnezhad F.   +5 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Do Individual Interests Make A Difference? [PDF]

, 1988
Renninger, K. Ann
core   +2 more sources

Effect of socioeconomic status as measured by education level on survival in breast cancer clinical trials

, 2011
James E. Herndon, Alice B. Kornblith, Jimmie C. Holland, Electra D. Paskett   +3 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source