Results 61 to 70 of about 1,476,402 (257)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Ecological correlation between diabetes hospitalizations and fine particulate matter in Italian provinces [PDF]

open access: yes, 2015
Background: Exposure to particulate matter has been associated with increased risk of cardiovascular and respiratory diseases. We evaluated the ecological correlation between standardized hospital discharges with diabetes in Italian provinces and fine ...
D'ADDARIO, MADDALENA   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Sumber Daya Manusia Pendidikan Dalam Menghadapi Era Industri 4.0. [PDF]

open access: yes, 2019
Indonesia is a developing country that is facing the Industrial Revolution 4.0 Era. Many things must be changed in a country if the country wants to become a developed country.
Safran, Safran, Salminawati, Salminawati
core  

Law-Based Arguments and Messages to Advocate for Later School Start Time Policies in the United States [PDF]

open access: yes, 2017
The increasing scientific evidence that early school start times are harmful to the health and safety of teenagers has generated much recent debate about changing school start times policies for adolescent students.
Lee, Clark J   +3 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Two new species of the genus Cylindrophis Wagler, 1828 (Squamata: Cylindrophiidae) from Southeast Asia [PDF]

open access: yes, 2015
© 2015 Amarasinghe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercialNoDerivatives 4.0 International License, which permits unrestricted use for non-commercial and education purposes only ...
Amarashinghe, AAT   +5 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Human Capital Management in the Industrial Revolution 4.0

open access: yesJournal of Human Resource Management, 2023
Purpose - The technological breakthrough known as the 4th Industrial Revolution is characterised by the mass spread of the Internet and its penetration into most human activities.
Jana Podhorcová   +2 more
doaj   +1 more source

Prevalence and correlates of achieving recommended physical activity levels among children living in rural South Asia—A multi-centre study [PDF]

open access: yes, 2016
Background: We report the prevalence of recommended physical activity levels (RPALs) and examine the correlates of achieving RPALs in rural South Asian children and analyse its association with anthropometric outcomes.
Alam, D   +6 more
core   +2 more sources

Home - About - Disclaimer - Privacy