Results 271 to 280 of about 482,786 (346)

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Co-Designing an Inclusive Stakeholder Engagement Strategy for Rehabilitation Technology Training Using the I-STEM Model. [PDF]

Int J Environ Res Public Health
Blake H, Abbott-Fleming V, Abdalrahim A, Horrocks M.   +3 more
europepmc   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

Developing a rehabilitation intervention difficulty index: A mixed-methods study using NASA-TLX and Borg RPE in a tertiary clinical setting. [PDF]

PLoS One
Temraz Y, Al Salem T, Al Nufaie Y, Aaltaza A, Almandoor M, Al-Subaie T, Alshalawi S, Alsaadoon S, Al Hussein A, Aldakhil M.   +9 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

UNIversity students' LIFEstyle behaviours and Mental health cohort (UNILIFE-M): study protocol of a multicentre, prospective cohort study. [PDF]

BMJ Open
Schuch FB, Waclawoscky A, Tornquist D, Oyeyemi AL, Sadarangani KP, Takano K, Teychenne M, Balanzá-Martínez V, O'Neil A, Romain AJ, McGrath A, Alselmi A, Andrade-Lima A, Zanetti ACG, Trompetero-González AC, Heissel A, Silva AFD, Benavides ACZ, Ruusunen A, Cristi-Montero C, Weise C, Pires DA, Silva DRP, Pelupessy DC, Dos Santos EB, Caputo EL, Critselis E, Dragioti E, Matthews E, de Jesus-Moraleida FR, Gomes FA, Bachtiar F, Silva-Junior FLE, Sallem H, Moura H, Womboh I, Grabovac I, Meyer JD, Ramos-Diaz J, Bueno-Antequera J, de Oliveira J, Deenik J, Soto-Sánchez J, van der Kaap-Deeder J, Leo Ng J, López-Gil JF, Firth J, Teixeira JA, Nikonov JR, Hoyer J, Carneiro L, Zou L, Farrer LM, Woud ML, Solmi M, Guimarães MEA, Gerber M, Reichert M, Jenkins M, Savage MJ, Hoffmann MS, Hutchesson M, Gonzalez Henao ME, Chong MJM, Morina N, Galvão-Coelho NL, Heinrichs N, Montoya-Hurtado OL, Ewah PA, Salameh P, De Boni R, Cheung RYM, Monteiro-Junior RS, White RL, Haider S, Baldew SS, Gow S, Rosenbaum S, Hallit S, Piccinin SG, Heinzel S, Torres S, Rashid T, Matias TS, Rohe T, Meireles T, Reyes-Ferrada W, Zhang Y, Frei AK, Deslandes A, Wolf S.   +90 more
europepmc   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Perceived determinants of clinical practice guideline implementation for stroke rehabilitation in LMICs a multinational REFORM survey. [PDF]

Sci Rep
Gandhi DB, Mascarenhas R, Vijayanand PJ, Fernandez CJ, Montanaro V, Kamlakannan S, Solomon JM, Urimubenshi G, Ngeh Ngeh E, Global Consortium of Stroke Rehabilitation (GCSR).   +9 more
europepmc   +1 more source

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Bridging the gap: Essential factors for poststroke community reintegration in low-and-middle income countries. [PDF]

PLoS One
Farooq FN, Nayak A, Kumar K V, Natarajan S, Pai S, Mascarenhas R.   +5 more
europepmc   +1 more source