Results 131 to 140 of about 455,239 (314)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Establishing a Modern Business Degree Education Program

, 2017
Business schools are required to constantly update their curricula to keep up with development in the business environment as well as to maintain competitive edge over other institutions in the academic sector. This paper addresses that need by proposing a methodology on how to device and construct a bachelor's degree program in business, as well as ...
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Training of IT specialists in regional universities of Russia and Europe based on international recommendations: comparative analysis

RUDN Journal of Informatization in Education
Problem statement. Studied the current issues in the development of IT university training in the context of global digitalization of economy and social sector.
Marina V. Khudzhina
doaj   +1 more source

Promoting interprofessionalism: initial evaluation of a master of science in health professions education degree program. [PDF]

Adv Med Educ Pract, 2016
Lamba S, Strang A, Edelman D, Navedo D, Soto-Greene ML, Guarino AJ.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Wildlife Photographs: Seeing, Caring, and Learning Through Place-Based Education

Frontiers in Education, 2022
Diane S. Wright, Diane S. Wright, Diane S. Wright, Kevin R. Crooks, Kevin R. Crooks, Meena M. Balgopal, Meena M. Balgopal   +6 more
doaj   +1 more source

Global health degree education in Europe： development， characteristics， and implications

Shanghai yufang yixue
After years of development, Europe has accumulated extensive experience in the discipline development and global health degree education, laying a strong foundation for cultivating professionals with a global perspective and practical competencies ...
FENG Zhen, HUANG Jiayan
doaj   +1 more source