Results 41 to 50 of about 499,263 (310)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Perspectives de croissance et de développement de l’éducation en Asie

Revue Internationale d’Éducation de Sèvres, 2015
Asia’s current rise to power, spearheaded by the two giants that are India and China, creates a number of expectations and aspirations with regard to development and education. There is talk of an “Asian century”.
Rangachar Govinda
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Intercultural Exchanges in Internationalization of University: Study-Abroad Doctoral Students’ Lived experiences in Iran [PDF]

Taḥqīqāt-i Farhangī-i Īrān, 2019
The present article describes and interprets the experiences of study-abroad doctoral students studying in Iran. The theoretical backgrounds behind the issue relate to "academic exchanges" and "doctoral studies" as important subdivisions of ...
Z. Niknam
doaj   +1 more source

An International Study in Competency Education: Postcards from Abroad [PDF]

, 2014
Acknowledging that national borders need not constrain our thinking, we have examined a selection of alternative academic cultures and, in some cases, specific schools, in search of solutions to common challenges we face when we consider reorganizing ...
Sara Frank Bristow, Susan Patrick
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Les logiciels libres

Revue Internationale d’Éducation de Sèvres, 1999
The « UNESCO-Netdays Project in Latin America and the Carribean » seeks to promote regional cooperative work through the use of free software and Internet in education. The Project gives a new basis for exchanges with European institutions.
Guillermo Lozano, Rodrigo Laurens
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Transactional Education and Transactional Educators: Fostering the Habit of “Using Intelligence Fully” [PDF]

, 2003
This paper calls into question the assumptions implicit in many traditional theories of moral agency; namely, the assumption that moral agency requires the agent to be disinterested, disengaged, and psychically distant in order to be a good moral agent ...
Lowe, Barbara J.
core   +1 more source

An investigation into international business collaboration in higher education organisations: a case study of international partnerships in four UK leading universities [PDF]

, 2006
Purpose - The purpose of this paper is to develop a comparative analysis of the main objectives of international institutional partnerships in four UK leading universities.
Al-Habaibeh, A, Ayoubi, R
core   +1 more source