Results 121 to 130 of about 564,919 (317)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Performance Assessment For Civil Engineering Curriculum
, 2008 The accreditation of engineering education programs by the Accreditation Board for Engineering and Technology (ABET) requires the direct assessment of student’s learning to ensure they meet the requirements of particular program outcomes.
Bardet, Jean-Pierre +2 more
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
MEPHI’S OLYMPIADS FOR SCHOOLCHILDREN
Высшее образование в России, 2017 The paper focuses on the activities of the National Research Nuclear University “MEPhI” in the sphere of organization of subject Olympiads for schoolchildren.
S. E. MURAVIEV, V. I. SKRYTNYI
doaj
, 2017 This work in progress seeks to examine the psychometric analysis of the motivated strategies for learning questionnaire (MSLQ) for assessing engineering students’ motivation and learning strategies.
Adesope, Olusola +5 more
core
What Every Engineer Should Know about Engineering Education [PDF]
, 2005 The purpose of this paper is to present the current status of the literature of engineering education. In order to accomplish this task several questions are discussed: Who publishes the documents? What are the topics of the articles published?
Osorio, Nestor L.
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source