Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
High Quality Differentiated Instruction - A Checklist for Teacher Professional Development on Handling Differences in the General Education Classroom [PDF]
, 2017 Wouter Smets
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دور القیادة الأخلاقیة فی تحقیق الفعالیة المدرسیة والرضا الوظیفی للمعلمین بمدارس التعلیم العام The Role of Ethical Leadership in Achieving School Effectiveness and Job Satisfaction among Teachers in the General Education Schools [PDF]
, 2020 مفرح سعید آل کردم
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Motivation in rural math education within general and special education settings
Frontiers in EducationIntroductionThis study examines how motivational processes in STEM education differ for rural students with and without Individualized Education Programs (IEPs) using Situated Expectancy-Value Theory (SEVT).
Haidee A. Jackson +2 more
doaj +1 more source
Comparison between the effects of flipped class and traditional methods of instruction on satisfaction, active participation, and learning level in a continuous medical education course for general practitioners [PDF]
, 2019 Mehrnoosh Khoshnoodi Far +4 more
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Evaluating the Symbol Binding Ability of Large Language Models for Multiple-Choice Questions in Vietnamese General Education [PDF]
, 2023 Duc-Vu Nguyen, Quoc-Nam Nguyen
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