Results 81 to 90 of about 233,294 (316)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The role of youth programmes in the transition from school to work [PDF]

The purpose of the study is to investigate how labour market regulation, modified by educational systems, affects the magnitude, composition and targeting of Youth Programmes.
Schröder, Lena
core  

The clinical effectiveness of different parenting programmes for children with conduct problems : a systematic review of randomised controlled trials [PDF]

, 2009
Background Conduct problems are common, disabling and costly. The prognosis for children with conduct problems is poor, with outcomes in adulthood including criminal behaviour, alcoholism, drug abuse, domestic violence, child abuse and a range of ...
Barlow Jane, Bayliss, S, Frew, Emma, Hyde Chris, Stewart-Brown Sarah, Stewart-Brown, Sarah, Sandercock Josie, Frew Emma, Davenport Clare, Taylor, Rod, Stewart-Brown, Sarah L., Davenport, Clare; id_orcid, Taylor, RS, Barlow, Jane, Taylor, Rod S., Bayliss Sue, Dretzke, Janine, Hyde, Christopher, Barlow, J, Davenport, Clare, Sandercock, Josie, Dretzke Janine, Bayliss, Sue, Stewart-Brown, S, Hyde, C, Hyde, Chris, Frew, Emma; id_orcid, Taylor Rod S   +27 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

OBLIGATORY PROGRAM AND ITS EFFICACY IN PATIENTS WITH OSTEOARTHRITIS

Научно-практическая ревматология, 2001
The aim of the research was to create education programme and investigate its effict in patients with osteoarthritis. The programme included 9 subjects, concerning of main questions of osteoarthritis self-control.
S S Yakushin, S. P. Filonenko, N V Minayeva, N A Rondaleva   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Clinical Legal Education Handbook

, 2020
The Clinical Legal Education Handbook is intended to act as a good practice guide and practical resource for those engaged in the design and delivery of clinical legal education programmes at university law schools.

core   +1 more source

Exploring Nursing and Medical Students’ Experiences of Handling Challenging Conversations: A Qualitative Focus Group Study

Advances in Medical Education and Practice
Germanus Natuhwera,1,2 Peter Ellis,3 Eve Namisango2,4,5 1Clinical & Administration Departments, Hospice Africa Uganda, Kampala, Uganda; 2Education Department, Institute of Hospice and Palliative Care in Africa, Kampala, Uganda; 3Independent Nursing ...
Natuhwera G, Ellis P, Namisango E
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

La littérature dans l’enseignement scolaire en Russie

Revue Internationale d’Éducation de Sèvres, 2012
In Russia, where literature is still a central feature, it is considered to be one of the main subjects of humanities, which must be studied by all pupils. Literature teaching at school is divided up into different levels depending on pupils’ age and the
Lioudmila Troubina, Viktor Chertov
doaj   +1 more source