Results 51 to 60 of about 233,294 (316)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Orientations et réalités de l’enseignement de l’histoire au Vietnam

Revue Internationale d’Éducation de Sèvres, 2015
As globalization intensifies, teaching in general, and the teaching of the history of nations in particular, both find themselves confronted with new opportunities and new issues.
Hoang Thanh Tu
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Employability programmes and work placements in higher education : a review of published evidence on employability programmes and work placements in UK higher education [PDF]

, 2021
Given the recent focus on the employability and earnings of university graduates in the UK, there is a need to explore the employability initiatives offered by higher education institutions (HEIs). Work placements and work experience offered through HEIs
Atfield, Gaby, Luchinskaya, Daria, Hunt, Wil   +2 more
core  

The Utility And Recommendations Of Adapted Physical Activity In The Care Of People With Autism Spectrum Disorder In A Sports Environment

مجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضية
This research aims to evaluate the impact of an adapted sports programme on children with autism spectrum disorder (ASD), through an experimental design based on a comparison between an experimental group that received the programme and a control group ...
ZENATI yassine, BENBERNOU Othmane, SEBBANE Mohamed   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Teaching te reo Māori as a second language in primary schools: two case studies.

, 2010
The provision of second language education in New Zealand primary schools has been, until recently, a rare addition to programmes. Its wider implementation in New Zealand primary schools has always been limited by low numbers of fluent bilingual teachers,
Hill, Richard Kenneth, Hill, Richard
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Exploring hybrid leadership’s influence on school-based support teams in no-fee primary schools

South African Journal of Childhood Education
Background: School-based support teams (SBSTs) play a crucial role in facilitating inclusive education in South African schools; however, their effectiveness often depends on the leadership style adopted within the school.
Mmapeu M. Manyaka, Francis Simui
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source