Results 111 to 120 of about 1,015,064 (290)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Are coach education programmes the most effective method for coach development? [PDF]
, 2016 The purpose of this study is to establish whether coaches from a multi-sport context develop most effectively through coach education programmes and whether formal learning is fostering coach effectiveness.
Lorimer, Ross, Maclean, Jordan
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Rates of qualification from postgraduate research degrees : projected study outcomes of full-time students starting postgraduate research degrees in 2008-09 and 2009-10 [PDF]
, 2012 "This report introduces a new approach to measuring rates of qualification from research degree study. It provides qualification rates of students on postgraduate research degree programmes at higher education institutions in England" - front ...
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Professional education for a digital world [PDF]
Reviews developments in initial professional education for library and information work in relation to contemporary university library practice in the digital world, with particular reference to the impact of technology on content and delivery. Discusses
Corrall, Sheila
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Selection and admission of students for social work education: key issues and debates in relation to practice and policy in England [PDF]
, 2010 This project set out to examine the recruitment and selection of students for social work degree programmes in England. Existing publicly available data were drawn from Higher Education Institution (HEI) websites, online prospectuses, UCAS1 databases ...
Holmstrom, Cath
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Incarcerated individuals and education programmes in Nigeria: A task for social workers. [PDF]
PLoS One, 2023 Uche IB +3 more
europepmc +1 more source