Results 71 to 80 of about 8,294,811 (306)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Prison educator's practice of adult education in prison education programmes: A Canadian case study
, 1991 Canada has advocated that education programmes offered in its federal prisons must be based in the principles of adult education. However, research in this area indicates that the implementation of adult education in Canadian federal prison education ...
Fox, Tricia A.
core +1 more source
Entre deux langues et deux approches didactiques
Revue Internationale d’Éducation de Sèvres, 2012 The issue of literature teaching in Haiti must be considered from a series of viewpoints: two types of literature, French and Haitian; two languages, French and creole; and two secondary teaching models, the traditional and the new.
Darline Alexis
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 1983 Meeting: International Committee on the Management of Population Programmes, International Conference ...
Sattar, E. +1 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Le Curriculum national en Angleterre : l’impératif d’une réforme
Revue Internationale d’Éducation de Sèvres, 2011 The paper outlines the current state of the National Curriculum in England, and examines accumulated problems which have culminated, in January 2011, in a announcement of a major review by the State.
Tim Oates
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Modèles de curricula et politiques curriculaires en Italie
Revue Internationale d’Éducation de Sèvres, 2011 This article describes the debate overthe curriculum in Italy over the last twenty years. Based on the change in design and practices ofthe curriculum in schools, the author offers a critical analysis of models, processes and control systems, and ...
Arduino Salatin
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source