Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
France : l’avancée du Socle commun et les questions posées
Revue Internationale d’Éducation de Sèvres, 2011 The French situation is analysed with reference to both the procedures inherent to the “content machine” and “products”, i.e. the teaching programmes in effect in 2011.
Roger-François Gauthier +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analysis of international graduate programmes structures for engineering education [PDF]
, 2010 This article traces the evolution of graduate study in Engineering in Ireland over three decades. Very few studies have shown the different norms and structures of graduate programmes in Ireland.
Brabazon, Dermot +3 more
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Developments in the evaluation of work-based learning: A UK perspective [PDF]
, 2004 UK higher education institutions are now expected to be able to demonstrate that they are adhering to the Code of Practice for the Assurance of Academic Quality and Standards in Higher Education in Placement Learning. The responsibility for ensuring that
Murdoch, Ian
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A comparison of the effectiveness of three parenting programmes in improving parenting skills, parent mental-well being and children's behaviour when implemented on a large scale in community settings in 18 English local authorities : the parenting early intervention pathfinder (PEIP) [PDF]
, 2011 Background There is growing evidence that parenting programmes can improve parenting skills and thereby the behaviour of children exhibiting or at risk of developing antisocial behaviour.
Davis, Hilton +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Directives pédagogiques et soubassement idéologique
Revue Internationale d’Éducation de Sèvres, 2012 The author presents thoughts on three generations of textbooks for learning French, the language of education and administration in Senegal, from two points of view: historical and didactic.
Abdoulaye Elimane Kane
doaj +1 more source
Assessment in vocational programmes in the further education sector in England: report from the Inspectorate (National survey report, January 1995) [PDF]
, 1995 This national survey report is concerned with the assessment of students attending all types of vocational education and training programmes offered by further education sector colleges in England.
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