Results 31 to 40 of about 548,405 (265)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Insuficiencia de los constructos psicológicos en la educación del altruismo Insuficiência dos construtos psicológicos no ensino do altruísmo Insufficiency of psychological constructs in education in altruism

Educación y Educadores, 2010
Con frecuencia los estudios relacionados con el altruismo lo abordan desde constructos psicológicos como la memoria, la afectividad, la motivación o el aprendizaje. Son escasas, en cambio, las aproximaciones desde la voluntad y la virtud.
Alfonso Osorio
doaj  

Art, music, and play as a teaching aid: applying creative uses of Universal Design for Learning in a prison science class

Frontiers in Education
Science, technology, engineering, and mathematics (STEM) subjects can be rigid in their teaching structure, creating barriers to education for students with more complex learning needs.
Philip J. Heron, Philip J. Heron, Fabio Crameri, Elisabetta Febe Canaletti, Dalton Harrison, Sara Hashemi, Phoenix Leigh, Sophia Narayan, Kiona Osowski, Rosa Rantanen, James A. Williams   +10 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Ideas Of Adult Education In Russian And Ukrainian Herritage End Of XIX – Beginning Of XX Centuries

International Journal of Social and Educational Innovation, 2017
Analyzed have been the ideas of adult education and its place in the pedagogical heritage at the end of XIX – beginning XX centuries. We studied on the basis of works of A. Schjapov, A. Pruhavin, V. Vahterov, P. Kazanzev , O. Hermonius, H.
Liudmyla Tymchuk
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

La ciencia y el sentido común: por la enseñanza de un sentido común crítico A ciência e o senso comum: ensinar o senso comum crítico Science and Common Sense: In Favor of the Teaching of Critical Common Sense

Educación y Educadores, 2010
Este artículo tiene como objetivo explorar algunas relaciones que se establecen entre la ciencia y el sentido común. Se parte de la reconstrucción de las tesis de la modernidad, donde se privilegia la ciencia en desmedro del sentido común; tal ...
Juan Carlos Aguirre-García, Luis Guillermo Jaramillo-Echeverri   +1 more
doaj  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source