Results 51 to 60 of about 548,405 (265)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Starting and running speed on the example of football clubs from Berlin
Quality in Sport, 2020 Currently, football is one of the most popular disciplines in the world. In the country of four-time World Champions, it is the most popular sport in which millions of fans and players are engaged.
Paweł Kalinowski +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
THE INTERNATIONAL INNOVATIVE UNIVERSITY AS A CENTER FOR THEORETICAL AND TECHNOLOGICAL INNOVATIONS
Высшее образование в России, 2016 The article considers the theoretical and methodological platform for development education and training process at the International Innovative University.
Lyudmila S. Dovgal’, Olga V. Nepsha
doaj
Education Theory Made Practical: Creating open educational resources via an apprenticeship model. [PDF]
AEM Educ Train, 2022 Gottlieb M +7 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Deployment Dynamic Modeling and Driving Schemes for a Ring-Truss Deployable Antenna
Chinese Journal of Mechanical EngineeringMesh reflector antennas are widely used in space tasks owing to their light weight, high surface accuracy, and large folding ratio. They are stowed during launch and then fully deployed in orbit to form a mesh reflector that transmits signals.
Baiyan He +5 more
doaj +1 more source
Development and students' evaluation of a blended online and offline pedagogy for physical education theory curriculum in China during the COVID-19 pandemic. [PDF]
Educ Technol Res Dev, 2022 Liu H +8 more
europepmc +1 more source