Results 111 to 120 of about 1,310,754 (239)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

DO PISA AO SISPAE: o estímulo ao estreitamento curricular

Revista de Políticas Públicas, 2019
This paper aims to analyze the relationship between the International Program for Student Assessment (PISA) and the Paraense Educational Assessment System (SisPAE) as instruments for measuring large-scale educational processes that induce a evaluation ...
Cassio Vale, Maria do Socorro Vasconcelos Pereira, Francisco Willams Campos Lima   +2 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Assessment of quality indicators in spanish higher military education

SHS Web of Conferences, 2016
The quality assessment is subject to multiple interpretations of its content and purpose, and also regarding to methods and techniques used to develop it.
Olmos Gómez Maria del Carmen, de Luna Emilio Berrocal, Olmedo Moreno Eva M., Eisman Leonor Buendía, López Jorge Expósito, Núñez Christian Sánchez, Ramírez Eva Aguaded, Moral Marciana Pegalajar, Ruiz Pelegrina Juan José   +8 more
doaj   +1 more source

Identifying Chinese Secondary Teachers' Needs for Professional Development Abroad [PDF]

, 2006
China is at a crucial point for reforming its education system and seeks professional development abroad for selective secondary teachers. In this study, 13 experienced Chinese physics teachers undertook an intensive four-week professional development ...
Hudson, Peter, Yeh, Andy
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Rating indicators system of evaluation teacher's activities in modern universities [PDF]

, 2017
В статті проаналізовано показники оцінювання професійної діяльності викладачів, зокрема науково-дослідницької, академічної, комерційної діяльностей які є ключовими при рейтингуванні університету та сприяють підвищенню його конкурентоспроможності. Описано
Буйницька, Оксана Петрівна, Морзе, Наталія Вікторівна   +1 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Test Equating in Educational Assessment: A Comprehensive Framework for Promoting Fairness, Validity, and Cross-Cultural Equity

Asian Journal of Assessment in Teaching and Learning
This study presents a comprehensive conceptual framework for equating in educational assessment, aimed at enhancing the accuracy, validity, and fairness of equating outcomes.
Caroline Alordiah, John Oji
doaj   +1 more source